尼日利亚拉各斯未经治疗的 HIV 贫血患者中细小病毒 B19 DNA 的检测：一项病例对照研究。

Parvovirus B19 DNA detection in treatment-naïve HIV anemic patients in Lagos, Nigeria: a case control study.

机构信息

Medical Microbiology and Parasitology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

College of Medicine of the University of Lagos, Medical Microbiology and Parasitology P.M.B. 12003, Idi-Araba, Surulere Lagos, Nigeria.

出版信息

Afr Health Sci. 2020 Mar;20(1):219-226. doi: 10.4314/ahs.v20i1.27.

DOI:10.4314/ahs.v20i1.27

PMID:33402910

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7750054/

Abstract

BACKGROUND

Parvovirus B19 (B19) has tropism for cells of the erythroid lineage, which may lead to transient inhibition of erythropoiesis. Several studies and case reports suggested that B19 infection may contribute significantly to severe chronic anemia in HIV infected persons.

OBJECTIVE

To detect parvovirus B19 DNA in treatment-naïve HIV patients.

METHODS

This was a case control retrospective study. One hundred nineteen anemic and 81 non-anemic treatment-naïve HIV infected patients participated in the study at the Lagos University Teaching Hospital, Lagos, Nigeria. Polymerase chain reaction was used to detect B19 DNA.

RESULTS

Out of 200 patients analysed, 13(6.5%) had parvovirus B19 DNA. Eight HIV patients with anemia had B19 DNA while five non-anemic HIV patients had B19 DNA. This suggests that the presence of B19 DNA in the blood of HIV positive individuals may contribute to anemia because the majority (61.5%) who were positive for B19 DNA had anemia as compared to the non-anemic control group (38.5%).

CONCLUSION

This study shows that the presence of B19 DNA in anemic HIV infected patients is not associated with chronic anaemia in HIV infection because no significant association exist.

摘要

背景

细小病毒 B19（B19）对红系细胞具有亲嗜性，这可能导致红细胞生成短暂抑制。几项研究和病例报告表明，B19 感染可能会显著导致 HIV 感染者出现严重慢性贫血。

目的

检测未经治疗的 HIV 患者中的细小病毒 B19 DNA。

方法

这是一项病例对照回顾性研究。在尼日利亚拉各斯大学教学医院，119 名贫血和 81 名非贫血的未经治疗的 HIV 感染患者参与了这项研究。采用聚合酶链反应检测 B19 DNA。

结果

在分析的 200 名患者中，有 13 名（6.5%）存在细小病毒 B19 DNA。8 名贫血的 HIV 患者有 B19 DNA，而 5 名非贫血的 HIV 患者有 B19 DNA。这表明 HIV 阳性个体血液中存在 B19 DNA 可能导致贫血，因为大多数（61.5%）阳性 B19 DNA 的患者存在贫血，而非贫血对照组（38.5%）。