人类免疫缺陷病毒感染患者中B19型人细小病毒的临床特征和实验室检查结果
Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients.
作者信息
Pereira Renata Freire Alves, Garcia Rita de Cássia Nasser Cubel, Azevedo Kátia Martins Lopes de, Setúbal Sérgio, Siqueira Marilda Agudo Mendonça Teixeira de, Oliveira Solange Artimos de
机构信息
Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2014 Apr;109(2):168-73. doi: 10.1590/0074-02760130312.
Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.
免疫功能低下的患者感染人细小病毒B19（B19V）时可能会发展为严重的慢性贫血。然而，对于坚持高效抗逆转录病毒治疗（HAART）的人类免疫缺陷病毒（HIV）感染患者而言，情况并非如此。在本研究中，我们调查了5例接受HAART且血清聚合酶链反应确诊感染B19V的HIV感染患者的临床病程。其中4例患者感染了1a基因型毒株，其余1例患者感染了3b基因型毒株。3例患者检测到贫血，但所有患者均康复，无需免疫球蛋白和/或输血。在所有病例中，主治医生均未怀疑B19V感染。感染基因型与临床病程之间无明显关联。在HAART时代，HIV阳性患者的B19V感染可能有限、轻微或不明显。
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