Chan Julie L, Babadjouni Robin, Sacks Wendy, Bannykh Serguei I, Tuchman Alexander
Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, USA.
Endocrinology, Cedars-Sinai Medical Center, Los Angeles, USA.
Cureus. 2020 Nov 28;12(11):e11743. doi: 10.7759/cureus.11743.
Tumoral calcinosis (TC) is an uncommon disease that has been linked to familial genetic mutations but can often be due to secondary causes such as chronic renal failure and hyperparathyroidism. There are rare instances of tumoral calcinosis induced by foreign body injections, often for cosmetic purposes. Here we describe operative management of spinal cord compression due to mineral oil injection induced tumoral calcinosis. A 54-year-old transgender female presented with signs of myelopathy so severe that she had become wheelchair bound. Labs demonstrated hypercalcemia and imaging of the neuroaxis revealed significant calcification resulting in cervicothoracic and lumbar central canal stenosis. Given symptomatic cervical spinal cord compression, she was taken to the OR for urgent laminectomy and decompression. Postoperatively, she recovered well and was ambulating independently by postoperative day (POD) 9. This is the first reported case of localized mineral oil injections causing distant calcification with subsequent symptomatic cord compression requiring operative intervention.
肿瘤性钙化（TC）是一种罕见疾病，与家族基因突变有关，但通常也可能由慢性肾衰竭和甲状旁腺功能亢进等继发原因引起。异物注射导致肿瘤性钙化的情况罕见，常因美容目的所致。在此，我们描述因矿物油注射引起肿瘤性钙化导致脊髓受压的手术治疗。一名54岁的变性女性出现严重脊髓病症状，以至于只能依靠轮椅行动。实验室检查显示高钙血症，神经轴成像显示有明显钙化，导致颈胸段和腰段中央管狭窄。鉴于有症状性颈段脊髓受压，她被送往手术室进行紧急椎板切除术和减压术。术后，她恢复良好，术后第9天即可独立行走。这是首例报道的局部矿物油注射导致远处钙化并随后出现有症状的脊髓受压需要手术干预的病例。
