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无直接振动放大反馈的非线性耳蜗力学

Nonlinear cochlear mechanics without direct vibration-amplification feedback.

作者信息

Altoè Alessandro, Shera Christopher A

机构信息

Auditory Research Center, Caruso Department of Otolaryngology, University of Southern California, Los Angeles, California 90033, USA.

出版信息

Phys Rev Res. 2020 Feb-Apr;2(1). doi: 10.1103/physrevresearch.2.013218. Epub 2020 Feb 26.

Abstract

Recent recordings from the mammalian cochlea indicate that although the motion of the basilar membrane appears actively amplified and nonlinear only at frequencies relatively close to the peak of the response, the internal motions of the organ of Corti display these same features over a much wider range of frequencies. These experimental findings are not easily explained by the textbook view of cochlear mechanics, in which cochlear amplification is controlled by the motion of the basilar membrane (BM) in a tight, closed-loop feedback configuration. This study shows that a simple phenomenological model of the cochlea inspired by the work of Zweig [J. Acoust. Soc. Am. , 1102 (2015)] can account for recent data in mouse and gerbil. In this model, the active forces are regulated indirectly, through the effect of BM motion on the pressure field across the cochlear partition, rather than via direct coupling between active-force generation and BM vibration. The absence of strong vibration-amplification feedback in the cochlea also provides a compelling explanation for the observed intensity invariance of fine time structure in the BM response to acoustic clicks.

摘要

最近对哺乳动物耳蜗的记录表明,尽管基底膜的运动似乎仅在相对接近响应峰值的频率处才被主动放大且呈现非线性,但柯蒂氏器的内部运动在更广泛的频率范围内都表现出这些相同的特征。这些实验结果很难用耳蜗力学的传统观点来解释,在传统观点中,耳蜗放大是由基底膜(BM)在紧密的闭环反馈配置中的运动控制的。本研究表明,一个受茨威格[《美国声学学会杂志》,1102(2015)]的工作启发而建立的简单耳蜗现象学模型可以解释最近在小鼠和沙鼠身上获得的数据。在这个模型中,主动力是通过基底膜运动对耳蜗隔板上压力场的影响来间接调节的,而不是通过主动力产生与基底膜振动之间的直接耦合。耳蜗中缺乏强烈的振动放大反馈也为观察到的基底膜对声脉冲响应中精细时间结构的强度不变性提供了一个令人信服的解释。

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