Newcastle University Medical School, Newcastle-upon-Tyne, UK.
Department of Urology, Freeman Hospital, Newcastle-upon-Tyne, UK.
World J Urol. 2021 Aug;39(8):3095-3101. doi: 10.1007/s00345-020-03564-7. Epub 2021 Jan 5.
To describe risk of UTI in Stone formers comparing to non-stone formers.
Retrospective cohort study using electronic records for patients across southern England. Stone formers referred to a tertiary referral centre in Southern England, comparator patients were age and sex matched with 3:1 ratio from same database. Those with no documentation were excluded. UTI defined using ICD-10 codes. Risk of UTI presented as hazard ratio with 95% confidence interval, generated using cox regression. Sample size calculated using 80% power and significance set at 0.05.
Eight hundred and nineteen stone formers were included after 1000 records were screened for inclusion, with 2477 age and sex matched non-stone formers extracted from the same database. Sample size was calculated at 287 per group. Stone formers were at significantly increased risk of developing a UTI (HR 5.67; 95% CI 4.52-7.18, p < 0.001). Median follow-up was 19 years (IQR: 15-22).
Kidney stone formers are at increased risk of developing urinary tract infections.
比较结石形成者和非结石形成者的尿路感染风险。
这是一项使用电子病历对英格兰南部患者进行的回顾性队列研究。结石形成者被转诊到英格兰南部的一家三级转诊中心，对照组患者则根据年龄和性别以 3:1 的比例从同一数据库中匹配。那些没有记录的患者被排除在外。尿路感染的定义采用 ICD-10 编码。使用 Cox 回归生成风险比及其 95%置信区间来表示尿路感染风险。使用 80%的功效计算样本量，并将显著性水平设定为 0.05。
在筛选了 1000 份记录以纳入研究后，纳入了 819 名结石形成者，从同一数据库中提取了 2477 名年龄和性别匹配的非结石形成者作为对照组。计算出每组的样本量为 287 例。结石形成者发生尿路感染的风险显著增加（HR 5.67；95%CI 4.52-7.18，p<0.001）。中位随访时间为 19 年（IQR：15-22）。
肾结石患者发生尿路感染的风险增加。
