Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
ACS Appl Mater Interfaces. 2021 Jan 20;13(2):2988-2996. doi: 10.1021/acsami.0c16550. Epub 2021 Jan 6.
Hollow graphene oxide microcapsules (GOMs) have been widely used in energy, electronics, catalysis, sensing, tissue engineering, and drug loading due to their unique properties. However, it is still a great challenge to prepare GOMs with high quality and in large quantity using a simple method. In this work, we obtained single-component GOMs using the liquid nitrogen cavitation effect, which directed the self-assembly of graphene oxide (GO) debris at the gas-liquid interface. This method avoids the introduction of additional components and removal of templates. The morphology of GOM with wrinkles on its surface was characterized by transmission electron microscopy and scanning electron microscopy. The abundant polar groups of GO microcapsules enabled them to easily disperse in water. Based on this, GOMs have good potential for loading hydrophobic drugs. Subsequently, we used GOMs as carriers to deliver a hydrophobic drug paclitaxel (PTX), which exhibited a good loading capacity. Moreover, PTX loaded GOMs showed excellent cytotoxicity to A549 and MDA-MB-231 cells. The GOMs also showed a pH-dependent drug release performance. Therefore, GOMs can be regarded as potential carriers for biomedical applications.
中空氧化石墨烯微胶囊 (GOMs) 由于其独特的性质，已被广泛应用于能源、电子、催化、传感、组织工程和药物负载等领域。然而，采用简单的方法制备高质量和大量的 GOMs 仍然是一个巨大的挑战。在这项工作中，我们利用液氮空化效应获得了单一组分的 GOMs，该效应指导了氧化石墨烯 (GO) 碎片在气液界面处的自组装。这种方法避免了引入额外的成分和模板的去除。通过透射电子显微镜和扫描电子显微镜对具有褶皱表面形貌的 GOM 进行了表征。GO 微胶囊丰富的极性基团使其易于在水中分散。基于这一点，GOMs 在负载疏水性药物方面具有良好的潜力。随后，我们将 GOMs 用作载体来输送疏水性药物紫杉醇 (PTX)，其表现出良好的载药能力。此外，负载 PTX 的 GOMs 对 A549 和 MDA-MB-231 细胞表现出优异的细胞毒性。GOMs 还表现出 pH 依赖性的药物释放性能。因此，GOMs 可以被视为生物医学应用的潜在载体。
