el-Mofty M M, Sakr S A, Osman S I, Toulan B A
Zoology Department, Faculty of Science, University of Alexandria, Egypt.
Oncology. 1989;46(1):63-5. doi: 10.1159/000226684.
Biscuits made of flour infested with Tribolium castaneum induced the formation of hepatocellular carcinomas (22%) when force-fed to toads (Bufo regularis) at a dose level of 200 mg/50 g 3 times a week. Maximal time of exposure and observation was 16 weeks. Some metastatic deposits from the primary liver tumours were found in the kidneys. Thus, the carcinogenic potency of the biscuits was almost the same as that of the flour previously reported by the authors indicating that the temperature of the oven in which the biscuits were baked did not alter the carcinogenicity of the infested flour.
用感染了赤拟谷盗的面粉制作的饼干，每周3次以200毫克/50克的剂量强制喂给蟾蜍（普通蟾蜍）时，会诱发肝细胞癌（22%）。最长暴露和观察时间为16周。在肾脏中发现了一些原发性肝肿瘤的转移灶。因此，这些饼干的致癌效力与作者之前报道的面粉几乎相同，这表明烘焙饼干的烤箱温度并未改变受感染面粉的致癌性。
