el-Mofty M M, Khudoley V V, Sakr S A, Fathala N G
Department of Zoology, Faculty of Science, Alexandria University, Egypt.
Nutr Cancer. 1992;17(1):97-104. doi: 10.1080/01635589209514176.
The carcinogenic effect of flour infested with beetles (Tribolium castaneum), biscuits made of this flour, and 1,4-benzoquinone (a quinoid secretion of this beetle) was investigated using Swiss albino mice. Force feeding flour infested with T. castaneum induced liver and spleen tumors (lympholeukemia) in 35.2% of the animals. The tumor incidence was 29% in mice force fed biscuits made of infested flour, and the tumors were located in the liver (lympholeukemia) and breast (adenocarcinoma type A). In animals fed 1,4-benzoquinone, the tumor incidence was 33.6%, and the tumors were located in the liver and spleen (lympholeukemia). It is speculated that 1,4-benzoquinone, alone or in combination with other quinoid secretions of the beetles present in the flour, may be responsible for tumor induction in the organs of mice.
利用瑞士白化小鼠研究了受甲虫（赤拟谷盗）侵染的面粉、用这种面粉制作的饼干以及1,4 - 苯醌（这种甲虫的醌类分泌物）的致癌作用。对受赤拟谷盗侵染的面粉进行强制喂食，导致35.2%的动物出现肝脏和脾脏肿瘤（淋巴细胞白血病）。用受侵染面粉制作的饼干对小鼠进行强制喂食，肿瘤发生率为29%，肿瘤位于肝脏（淋巴细胞白血病）和乳腺（A型腺癌）。给动物喂食1,4 - 苯醌，肿瘤发生率为33.6%，肿瘤位于肝脏和脾脏（淋巴细胞白血病）。据推测，1,4 - 苯醌单独或与面粉中存在的甲虫的其他醌类分泌物共同作用，可能是导致小鼠器官肿瘤发生的原因。
