Department of Pharmaceutical Microbiology at the Hans Knöll Institute, Friedrich-Schiller-University Jena, Winzerlaer Strasse 2, 07745 Jena, Germany.
Nat Prod Rep. 2021 Apr 28;38(4):702-722. doi: 10.1039/d0np00077a.
Covering: up to September 2020 Mushroom-forming fungi of the division Basidiomycota have traditionally been recognised as prolific producers of structurally diverse and often bioactive secondary metabolites, using the methods of chemistry for research. Over the past decade, -omics technologies were applied on these fungi, and sophisticated heterologous gene expression platforms emerged, which have boosted research into the genetic and biochemical basis of the biosyntheses. This review provides an overview on experimentally confirmed natural product biosyntheses of basidiomycete polyketides, amino acid-derived products, terpenoids, and volatiles. We also present challenges and solutions particular to natural product research with these fungi. 222 references are cited.
截至 2020 年 9 月，担子菌门的担子菌形成真菌传统上被认为是结构多样且通常具有生物活性的次生代谢产物的丰富生产者，研究方法是化学方法。在过去的十年中，组学技术被应用于这些真菌，并且出现了复杂的异源基因表达平台，这极大地促进了对生物合成的遗传和生化基础的研究。本综述概述了担子菌聚酮类、氨基酸衍生产物、萜类化合物和挥发物的经实验证实的天然产物生物合成。我们还介绍了这些真菌进行天然产物研究的特殊挑战和解决方案。本文引用了 222 篇参考文献。
