Yamamoto L G, Ashton M J
Department of Pediatrics, University of Hawaii John A. Burns School of Medicine, Honolulu.
Pediatr Infect Dis J. 1988 Jan;7(1):48-52. doi: 10.1097/00006454-198801000-00012.
In a 10-year cohort of 117 infants hospitalized in Honolulu with Salmonella infections, there were 12 infants with bacteremia or complications (simple bacteremia, 7; bacteremia with probably unrelated concurrent infection, 2; serious complications, 3). The rate of serious complications in this cohort was low and occurred only in infants with previous chronic illness or clinically obvious extraintestinal infection at the time of presentation. Antibiotics were not shown to be of benefit in reducing the frequency of complications; however, the sample size was too small to make definitive conclusions. These data do not support the contention that infants with Salmonella gastroenteritis are at increased risk of complications and should therefore be treated with antibiotics. Rather, the same clinical risk factors for sepsis that apply to all infants also apply to infants with Salmonella gastroenteritis and the decision to begin antibiotic treatment should be based on similar clinical information.
在檀香山一家医院住院的117名感染沙门氏菌的婴儿组成的10年队列中，有12名婴儿出现菌血症或并发症（单纯菌血症7例；可能与并发感染无关的菌血症2例；严重并发症3例）。该队列中严重并发症的发生率较低，且仅发生在就诊时患有既往慢性病或临床上明显的肠外感染的婴儿中。未显示抗生素在降低并发症发生率方面有任何益处；然而，样本量过小，无法得出明确结论。这些数据不支持沙门氏菌性肠胃炎婴儿并发症风险增加、因此应使用抗生素治疗这一观点。相反，适用于所有婴儿的脓毒症临床风险因素同样适用于沙门氏菌性肠胃炎婴儿，开始抗生素治疗的决定应基于类似的临床信息。
