Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Department of Physical Therapy, Graduate School of Inje University, Gimhae, Korea.
Mol Neurobiol. 2021 May;58(5):1917-1931. doi: 10.1007/s12035-020-02239-z. Epub 2021 Jan 6.
The new coronavirus (CoV), called novel coronavirus disease 2019 (COVID-19), belongs to the Coronaviridae family which was originated from the sea market in Wuhan city in China, at the end of the year 2019. COVID-19 and severe acute respiratory syndrome (SARS) are belonging to the same family (Coronaviridae). The current outbreak of COVID-19 creates public concern and threats all over the world and now it spreads out to more than 250 countries and territories. The researchers and scientists from all over the world are trying to find out the therapeutic strategies to abate the morbidity and mortality rate of the COVID-19 pandemic. The replication, spreading, and severity of SARS-CoV2 depend on environmental settings. Noteworthy, meteorological parameters are considered as crucial factors that affect respiratory infectious disorders, although the controversial effect of the meteorological parameter is exposed against COVID-19. Besides, COVID-19 accelerates the pathogenesis of the neurological disorders. However, the pathogenic mechanisms between COVID-19 and neurological disorders are still unclear. Hence, this review is focused on the genomics and ecology of SARS-CoV2 and elucidated the effects of climatic factors on the progression of COVID-19. This review also critically finds out the vulnerability between COVID-19 and neurological disorders based on the latest research data.
新型冠状病毒（CoV），又称 2019 年新型冠状病毒病（COVID-19），属于冠状病毒科，于 2019 年末起源于中国武汉市的海鲜市场。COVID-19 和严重急性呼吸综合征（SARS）同属冠状病毒科（Coronaviridae）。目前 COVID-19 的爆发引起了全世界的关注和威胁，现已蔓延到 250 多个国家和地区。来自世界各地的研究人员和科学家正在努力寻找治疗策略，以降低 COVID-19 大流行的发病率和死亡率。SARS-CoV2 的复制、传播和严重程度取决于环境因素。值得注意的是，气象参数被认为是影响呼吸道传染病的关键因素，尽管气象参数对 COVID-19 的影响存在争议。此外，COVID-19 加速了神经系统疾病的发病机制。然而，COVID-19 和神经系统疾病之间的发病机制尚不清楚。因此，本综述重点关注 SARS-CoV2 的基因组学和生态学，并阐明了气候因素对 COVID-19 进展的影响。本综述还根据最新的研究数据，批判性地发现了 COVID-19 和神经系统疾病之间的脆弱性。
