Singh Rachana, Singh Pradhyumna Kumar, Kumar Rajnish, Kabir Md Tanvir, Kamal Mohammad Amjad, Rauf Abdur, Albadrani Ghadeer M, Sayed Amany A, Mousa Shaker A, Abdel-Daim Mohamed M, Uddin Md Sahab
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, India.
Plant Molecular Biology and Biotechnology Division, Council of Scientific and Industrial Research- National Botanical Research Institute (CSIR-NBRI), Lucknow, India.
Front Pharmacol. 2021 May 12;12:652335. doi: 10.3389/fphar.2021.652335. eCollection 2021.
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has a disastrous effect on mankind due to the contagious and rapid nature of its spread. Although vaccines for SARS-CoV-2 have been successfully developed, the proven, effective, and specific therapeutic molecules are yet to be identified for the treatment. The repurposing of existing drugs and recognition of new medicines are continuously in progress. Efforts are being made to single out plant-based novel therapeutic compounds. As a result, some of these biomolecules are in their testing phase. During these efforts, the whole-genome sequencing of SARS-CoV-2 has given the direction to explore the omics systems and approaches to overcome this unprecedented health challenge globally. Genome, proteome, and metagenome sequence analyses have helped identify virus nature, thereby assisting in understanding the molecular mechanism, structural understanding, and disease propagation. The multi-omics approaches offer various tools and strategies for identifying potential therapeutic biomolecules for COVID-19 and exploring the plants producing biomolecules that can be used as biopharmaceutical products. This review explores the available multi-omics approaches and their scope to investigate the therapeutic promises of plant-based biomolecules in treating SARS-CoV-2 infection.
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起。由于其传播具有传染性和快速性，它对人类产生了灾难性影响。尽管已经成功开发出针对SARS-CoV-2的疫苗，但尚未确定经过验证的、有效的和特异性的治疗分子用于治疗。现有药物的重新利用和新药的识别工作正在持续进行。人们正在努力筛选基于植物的新型治疗化合物。因此，其中一些生物分子正处于测试阶段。在这些努力过程中，SARS-CoV-2的全基因组测序为探索组学系统和方法以应对全球这一前所未有的健康挑战指明了方向。基因组、蛋白质组和宏基因组序列分析有助于识别病毒特性，从而有助于理解分子机制、结构认识和疾病传播。多组学方法提供了各种工具和策略，用于识别针对COVID-19的潜在治疗生物分子，并探索能够产生可作为生物制药产品的生物分子的植物。本综述探讨了可用的多组学方法及其在研究基于植物的生物分子治疗SARS-CoV-2感染的治疗前景方面的应用范围。
