Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain.
Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Drug Deliv Transl Res. 2021 Apr;11(2):515-523. doi: 10.1007/s13346-020-00880-8. Epub 2021 Jan 6.
Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (superparamagnetic iron oxide nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX. Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.
神经胶质瘤是一种预后极差的癌症，多形性胶质母细胞瘤（GBM）的存活期约为 15 个月。为了在个性化医疗方面取得进展，我们开发了载有超顺磁氧化铁纳米颗粒（SPION）和阿霉素（DOX）的聚合物纳米颗粒（PNP）。前者用于其在强磁场下将 PNP 聚集在肿瘤中的潜力，后者用于其治疗潜力。选择乳液溶剂蒸发法来开发具有高载药效率的单分散 PNP，对 SPION 和 DOX 均如此。一旦将其注入小鼠体内，在静磁场下通过 MRI 观察到 PNP 在肿瘤组织内大量聚集，从而导致肿瘤生长速度降低。
