过敏反应：儿科过敏诊所的常见现象。
Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics.
机构信息
Division of Allergy, Pulmonology, and Sleep Medicine, Department of Pediatrics, Children's Hospital and Medical Center, University of Nebraska Medical Center, Omaha, Nebraska.
出版信息
Pediatr Allergy Immunol Pulmonol. 2020 Mar;33(1):12-18. doi: 10.1089/ped.2019.1109. Epub 2020 Mar 2.
Abstract
The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.
摘要
超敏反应的解释长期以来一直依赖于 Gell 和 Coombs 的分类，该分类最初于 20 世纪 60 年代提出。然而，他们的概念至少早于其他作者 50 年。21 世纪的儿科过敏诊所每天都会提供多个这些基本概念的例子。我们回顾了原始标准的经典和不太经典的例子，强调了当前疾病病理生理学并不总是符合原始模型的地方，并为常见和不常见的免疫驱动的超敏反应性疾病提供了更新的语言。
相似文献
1
Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics.
Pediatr Allergy Immunol Pulmonol. 2020 Mar;33(1):12-18. doi: 10.1089/ped.2019.1109. Epub 2020 Mar 2.
2
The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation.
Trends Immunol. 2003 Jul;24(7):376-9. doi: 10.1016/s1471-4906(03)00142-x.
3
Allergy: Type I, II, III, and IV.
Handb Exp Pharmacol. 2022;268:31-41. doi: 10.1007/164_2021_510.
4
[Immunological bases and classification of allergy].
Arch Pediatr. 1999;6 Suppl 1:20S-28S. doi: 10.1016/s0929-693x(99)80242-5.
5
Classification of hypersensitivity reactions.
Allergy Asthma Proc. 2019 Nov 1;40(6):470-473. doi: 10.2500/aap.2019.40.4274.
6
A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases.
Allergy. 2003 Sep;58(9):921-8. doi: 10.1034/j.1398-9995.2003.00227.x.
7
Chapter 28: Classification of hypersensitivity reactions.
Allergy Asthma Proc. 2012 May-Jun;33 Suppl 1:96-99. doi: 10.2500/aap.2012.33.3561.
8
[The revised Gell and Coombs classification: a new reading of old truths in the context of immunodeficiencies theory].
Lik Sprava. 2012 Jan-Mar(1-2):28-44.
9
Executive summary of disease management of drug hypersensitivity: a practice parameter. Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma and Immunology, the American Academy of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology.
Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 3):665-700.
10
The pathophysiology of ocular allergy: a review.
Cont Lens Anterior Eye. 2009 Feb;32(1):3-15; quiz 43-4. doi: 10.1016/j.clae.2008.07.003. Epub 2008 Sep 19.
引用本文的文献
1
Chimeric Autoantibody Receptor- and/or Peptide-MHC-Based CAR Therapies for Targeted Elimination of Antigen-Specific B or T Cells in Hypersensitivity Disorders Such as Allergies and Autoimmune Diseases.
Cells. 2025 May 21;14(10):753. doi: 10.3390/cells14100753.
2
Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract.
Immunol Res. 2025 Mar 11;73(1):60. doi: 10.1007/s12026-025-09606-9.
3
The last step to achieve barrier damage control.
Front Immunol. 2024 Feb 13;15:1354556. doi: 10.3389/fimmu.2024.1354556. eCollection 2024.
4
Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary.
Clin Rev Allergy Immunol. 2022 Feb;62(1):145-159. doi: 10.1007/s12016-020-08818-1. Epub 2020 Nov 26.
本文引用的文献
1
Cephalosporin Allergy: Current Understanding and Future Challenges.
J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001.
2
Management of chronic urticaria in children: a clinical guideline.
Ital J Pediatr. 2019 Aug 15;45(1):101. doi: 10.1186/s13052-019-0695-x.
3
Phenotypes and endotypes of adult asthma: Moving toward precision medicine.
J Allergy Clin Immunol. 2019 Jul;144(1):1-12. doi: 10.1016/j.jaci.2019.05.031.
4
Strength in numbers: The quest for asthma genes.
J Allergy Clin Immunol. 2019 Aug;144(2):413-415. doi: 10.1016/j.jaci.2019.06.007. Epub 2019 Jun 20.
5
A cellular census of human lungs identifies novel cell states in health and in asthma.
Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17.
6
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Lancet Respir Med. 2019 Jun;7(6):509-522. doi: 10.1016/S2213-2600(19)30055-4. Epub 2019 Apr 27.
7
Role of innate lymphoid cells in allergic diseases.
Allergy Asthma Proc. 2019 May 1;40(3):138-145. doi: 10.2500/aap.2019.40.4217.
8
Modern Inflammatory Phenotyping of Asthma. Breathomics Is Here to Stay.
Am J Respir Crit Care Med. 2019 Aug 15;200(4):405-406. doi: 10.1164/rccm.201904-0733ED.
9
Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma.
Am J Respir Crit Care Med. 2019 Aug 15;200(4):444-453. doi: 10.1164/rccm.201811-2210OC.
10
Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma.
J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1803-1812.e10. doi: 10.1016/j.jaip.2018.12.027. Epub 2019 Jan 14.
Zotero 插件