Charité-Universitätsmedizin, Institute of Biochemistry, Charitéplatz 1, 10117 Berlin, Germany.
Int J Mol Sci. 2021 Jan 4;22(1):430. doi: 10.3390/ijms22010430.
Ferroptosis has been described recently as an iron-dependent cell death driven by peroxidation of membrane lipids. It is involved in the pathogenesis of a number of diverse diseases. From the other side, the induction of ferroptosis can be used to kill tumor cells as a novel therapeutic approach. Because of the broad clinical relevance, a comprehensive understanding of the ferroptosis-controlling protein network is necessary. Noteworthy, several proteins from this network are flavoenzymes. This review is an attempt to present the ferroptosis-related flavoproteins in light of their involvement in anti-ferroptotic and pro-ferroptotic roles. When available, the data on the structural stability of mutants and cofactor-free apoenzymes are discussed. The stability of the flavoproteins could be an important component of the cellular death processes.
铁死亡最近被描述为一种依赖铁的细胞死亡，由膜脂质过氧化驱动。它参与了许多不同疾病的发病机制。另一方面，诱导铁死亡可以作为一种新的治疗方法来杀死肿瘤细胞。由于其广泛的临床相关性，全面了解铁死亡控制蛋白网络是必要的。值得注意的是，该网络中的几种蛋白质是黄素酶。本综述试图根据它们在抗铁死亡和促铁死亡作用中的作用，介绍与铁死亡相关的黄素蛋白。只要有可用的数据，就讨论突变体和无辅因子脱辅基酶的结构稳定性。黄素蛋白的稳定性可能是细胞死亡过程的一个重要组成部分。
