Zhong Yafang, Zhang Wei, Yu Haiyan, Lin Liewen, Gao Xucan, He Jingquan, Li Dandan, Chen Yumei, Zeng Zhipeng, Xu Yong, Tang Donge, Dai Yong
Department of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China.
Innovative Markers Department, Guangdong Fapon Biopharma Inc, Dongguan 523808, China.
iScience. 2022 Jul 15;25(8):104750. doi: 10.1016/j.isci.2022.104750. eCollection 2022 Aug 19.
Ferroptosis is a type of programmed cell death potentially playing an important role in colorectal cancer (CRC) development. However, comprehensive investigations toward ferroptosis in human CRC are lacking. Here, we performed multiple investigations on cancer and para-cancer tissues. We demonstrated that the changes of structural variation and chromatin accessibility in CRC were more associated with the altered mRNA expression of ferroptosis-related genes (FRGs), and the expression of , , , and was related to the overall survival rates. Subsequently, we revealed that and were potentially the hub genes, and that and were potentially FRGs' upstream transcription factors. Finally, we depicted the crosstalk between ferroptosis and necrosis, autophagy, and apoptosis. Based on multi-dimensional analyses, we characterized ferroptosis, probable core genes, and the upstream regulators in human CRC. The findings here may improve our understanding of ferroptosis in CRC and provide new opportunities for clinical diagnosis and treatment.
铁死亡是一种程序性细胞死亡类型，可能在结直肠癌（CRC）的发展中起重要作用。然而，目前缺乏对人类结直肠癌中铁死亡的全面研究。在此，我们对癌组织和癌旁组织进行了多项研究。我们证明，结直肠癌中结构变异和染色质可及性的变化与铁死亡相关基因（FRGs）的mRNA表达改变更相关，并且 、 、 和 的表达与总生存率相关。随后，我们发现 和 可能是核心基因，并且 和 可能是FRGs的上游转录因子。最后，我们描绘了铁死亡与坏死、自噬和凋亡之间的相互作用。基于多维度分析，我们对人类结直肠癌中的铁死亡、可能的核心基因和上游调节因子进行了表征。此处的研究结果可能会增进我们对结直肠癌中铁死亡的理解，并为临床诊断和治疗提供新的机会。
