Warwick Medical School, University of Warwick, Coventry, CV5 6AB, UK.
Department of Statistics, University of Warwick, Coventry, CV5 6AB, UK.
BMC Pregnancy Childbirth. 2021 Jan 6;21(1):10. doi: 10.1186/s12884-020-03478-7.
Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period METHODS: Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.
Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation.
Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface.
NCT01577147 . Date of registration 13 April 2012.
大多数孕妇在怀孕期间都会经历恶心和呕吐。发病通常与末次月经（LMP）有关，而末次月经日期往往不可靠。本研究描述了从排卵日期到恶心和呕吐症状开始的时间，并将其与末次月经日期进行了比较。
这是一项从 2014 年 5 月 12 日至 2016 年 11 月 25 日在英国招募的、试图怀孕的女性的前瞻性队列研究。256 名试图怀孕的女性每天记录恶心和呕吐日记。主要结局指标是从末次月经（LMP）或黄体生成素激增到恶心或呕吐开始的天数。
几乎所有女性（88%）在排卵后 8 至 10 天内出现人绒毛膜促性腺激素升高；相当于从末次月经开始的间隔为 20 至 30 天。许多女性（67%）在排卵后 11 至 20 天内出现症状。
恶心和呕吐的发作时间比以前报道的更早，症状发作的时间窗口很窄。这表明其病因与胎儿-母体界面的特定发育阶段有关。
NCT01577147。注册日期 2012 年 4 月 13 日。
