Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang Province, China.
Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang Province, China.
BMC Med Imaging. 2021 Jan 6;21(1):4. doi: 10.1186/s12880-020-00541-9.
The aim of the present study was to explore the brain active characteristics of patients with irritable bowel syndrome with diarrhea (IBS-D) using resting-state functional magnetic resonance imaging technology.
Thirteen IBS-D patients and fourteen healthy controls (HC) were enrolled. All subjects underwent head MRI examination during resting state. A voxel-based analysis of fractional amplitude of low frequency fluctuation (fALFF) maps between IBS-D and HC was performed using a two-sample t-test. The relationship between the fALFF values in abnormal brain regions and the scores of Symptom Severity Scale (IBS-SSS) were analyzed using Pearson correlation analysis.
Compared with HC, IBS-D patients had lower fALFF values in the left medial superior frontal gyrus and higher fALFF values in the left hippocampus and right precuneus. There was a positive correlation between the duration scores of IBS-SSS and fALFF values in the right precuneus.
The altered fALFF values in the medial superior frontal gyri, left hippocampus and right precuneus revealed changes of intrinsic neuronal activity, further revealing the abnormality of gut-brain axis of IBS-D.
本研究旨在使用静息态功能磁共振成像技术探索腹泻型肠易激综合征（IBS-D）患者的大脑活动特征。
纳入 13 例 IBS-D 患者和 14 例健康对照者（HC）。所有受试者均在静息状态下进行头部 MRI 检查。采用两样本 t 检验对 IBS-D 与 HC 之间的低频振幅分数（fALFF）图进行基于体素的分析。采用 Pearson 相关分析分析异常脑区的 fALFF 值与症状严重程度量表（IBS-SSS）评分之间的关系。
与 HC 相比，IBS-D 患者左侧额上内侧回的 fALFF 值较低，左侧海马和右侧楔前叶的 fALFF 值较高。IBS-SSS 评分的持续时间与右侧楔前叶的 fALFF 值呈正相关。
内侧额上回、左侧海马和右侧楔前叶的 fALFF 值改变表明内在神经元活动发生变化，进一步揭示了 IBS-D 的肠-脑轴异常。
