Wang Yi, Huang Yu-Wei, Ablikim Dilnur, Lu Qun, Zhang Ai-Jia, Dong Ye-Qing, Zeng Fei-Cui, Xu Jing-Hua, Wang Wen, Hu Zhi-Hai
Department of Acupuncture and Moxibustion, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
Department of Acupuncture and Moxibustion, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
World J Clin Cases. 2022 Jan 21;10(3):929-938. doi: 10.12998/wjcc.v10.i3.929.
Depression affects more than 350 million people worldwide. In China, 4.2% (54 million people) of the total population suffers from depression. Psychotherapy has been shown to change cognition, improve personality, and enhance the ability to cope with difficulties and setbacks. While pharmacotherapy can reduce symptoms, it is also associated with adverse reactions and relapse after drug withdrawal. Therefore, there has been an increasing emphasis placed on the use of non-pharmacological therapies for depression. The hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of depression.
To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with depression.
This randomized controlled trial included patients with mild to moderate depression ( = 160). Patients received either acupuncture at ghost points combined with fluoxetine ( = 80) or fluoxetine alone (control group, = 80). Needles were retained in place for 30 min, 5 times a week; three treatment cycles were administered. The Mann-Whitney U test was used to compare functional magnet resonance imaging parameters, Hamilton depression rating scale (HAMD) scores, and self-rating depression scale (SDS) scores between the acupuncture group and control group.
There were no significant differences in HAMD or SDS scores between the acupuncture group and control group, before or after 4 wk of treatment. The acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment ( < 0.05). The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf, left posterior cingulate gyrus, left middle occipital gyrus, and left inferior occipital gyrus after 8 wk. The acupuncture group also had significantly higher values for the right inferior frontal gyrus, right insula, and right hippocampus ( < 0.05). After 8 wk of treatment, the effective rates of the acupuncture and control groups were 51.25% and 36.25%, respectively ( < 0.05).
The study results suggest that acupuncture at ghost points combined with fluoxetine is more effective than fluoxetine alone for the treatment of patients with mild to moderate depression.
抑郁症影响着全球超过3.5亿人。在中国，总人口的4.2%（5400万人）患有抑郁症。心理治疗已被证明可以改变认知、改善性格，并增强应对困难和挫折的能力。虽然药物治疗可以减轻症状，但它也与不良反应以及停药后的复发有关。因此，人们越来越重视使用非药物疗法治疗抑郁症。本研究的假设是，鬼穴针刺联合氟西汀治疗抑郁症比单纯使用氟西汀更有效。
探讨鬼穴针刺联合氟西汀治疗抑郁症患者的疗效。
本随机对照试验纳入了轻度至中度抑郁症患者（ = 160）。患者接受鬼穴针刺联合氟西汀治疗（ = 80）或单纯氟西汀治疗（对照组, = 80）。留针30分钟，每周5次；进行三个治疗周期。采用曼-惠特尼U检验比较针刺组和对照组之间的功能磁共振成像参数、汉密尔顿抑郁量表（HAMD）评分和自评抑郁量表（SDS）评分。
治疗4周前后，针刺组和对照组的HAMD或SDS评分均无显著差异。治疗8周后，针刺组的HAMD和SDS评分显著低于对照组（ < 0.05）。治疗8周后，针刺组左侧前楔叶、左侧后扣带回、左侧枕中回和左侧枕下回的低频振幅分数值显著降低。针刺组右侧额下回、右侧岛叶和右侧海马体的值也显著升高（ < 0.05）。治疗8周后，针刺组和对照组的有效率分别为51.25%和36.25%（ < 0.05）。
研究结果表明，鬼穴针刺联合氟西汀治疗轻度至中度抑郁症患者比单纯使用氟西汀更有效。
