特发性肺纤维化患者的气胸：真实世界经验。
Pneumothorax in patients with idiopathic pulmonary fibrosis: a real-world experience.
机构信息
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
出版信息
BMC Pulm Med. 2021 Jan 6;21(1):5. doi: 10.1186/s12890-020-01370-w.
BACKGROUND
Some patients with idiopathic pulmonary fibrosis (IPF) develop pneumothorax. However, the characteristics of pneumothorax in patients with IPF have not been elucidated. The purpose of this study was to clarify the clinical course, actual management, and treatment outcomes of pneumothorax in patients with IPF.
METHODS
Consecutive patients with IPF who were admitted for pneumothorax between January 2008 and December 2018 were included. The success rates of treatment for pneumothorax, hospital mortality, and recurrence rate after discharge were examined.
RESULTS
During the study period, 36 patients with IPF were admitted with pneumothorax a total of 58 times. During the first admission, 15 patients (41.7%) did not receive chest tube drainage, but 21 (58.3%) did. Of the 21 patients, 8 (38.1%) received additional therapy after chest drainage. The respective treatment success rates were 86.6% and 66.7% in patients who underwent observation only vs chest tube drainage. The respective hospital mortality rates were 13.3% and 38.0%. The total pneumothorax recurrence rate after hospital discharge was 34.6% (n = 9).
CONCLUSIONS
Pneumothorax in patients with IPF was difficult to treat successfully, had a relatively poor prognosis, and showed a high recurrence rate.
背景
一些特发性肺纤维化（IPF）患者会发生气胸。然而，IPF 患者气胸的特征尚未阐明。本研究旨在阐明 IPF 患者气胸的临床过程、实际管理和治疗结果。
方法
纳入 2008 年 1 月至 2018 年 12 月期间因气胸入院的连续 IPF 患者。检查气胸治疗成功率、住院死亡率和出院后复发率。
结果
在研究期间，36 名 IPF 患者共发生 58 次气胸。首次入院时，15 名患者（41.7%）未接受胸腔引流管引流，但 21 名患者（58.3%）接受了引流。在这 21 名患者中，8 名（38.1%）在胸腔引流后接受了额外治疗。仅观察与胸腔引流的治疗成功率分别为 86.6%和 66.7%。相应的住院死亡率分别为 13.3%和 38.0%。出院后气胸总复发率为 34.6%（n=9）。
结论
IPF 患者的气胸难以成功治疗，预后较差，复发率较高。
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