Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan.
General Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
BMC Oral Health. 2021 Jan 6;21(1):4. doi: 10.1186/s12903-020-01373-3.
Metabolic syndrome (MetS), caused by the accumulation of visceral fat, is considered a major cause of cardiovascular disease. This randomized controlled trial aimed to clarify the effect of dental intervention, including prosthodontics and/or periodontal treatment, combined with dietary and exercise guidance on MetS.
In total, 112 patients who met the Japanese waist circumference criteria of MetS were recruited. The intervention group (ITG) received dental intervention along with dietary and exercise guidance, while the control group (CTG) received dietary and exercise guidance alone. Three outcome measurements were obtained before intervention (BL), 1 month after intervention (1M), and 3 months after intervention (3M).
Body water rate (p = 0.043) was significantly higher in ITG than in CTG at 1M. Simultaneously, fasting blood sugar level (p = 0.098) tended to be lower in ITG than in CTG. Lean mass (p = 0.037) and muscle mass (p = 0.035) were significantly higher and body weight (p = 0.044) significantly lower in ITG than in CTG at 3M. Body mass index (p = 0.052) tended to be lower in ITG than in CTG.
Dental intervention combined with lifestyle guidance may improve anthropometric status and reduce the risk of MetS.
University Hospital Medical Information Network Center Unique UMIN000022753. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026176 .
代谢综合征（MetS）是由内脏脂肪堆积引起的，被认为是心血管疾病的主要原因。本随机对照试验旨在阐明牙科干预（包括修复治疗和/或牙周治疗）联合饮食和运动指导对 MetS 的影响。
共招募了 112 名符合 MetS 日本腰围标准的患者。干预组（ITG）接受牙科干预以及饮食和运动指导，对照组（CTG）仅接受饮食和运动指导。在干预前（BL）、干预后 1 个月（1M）和干预后 3 个月（3M）进行了 3 项结果测量。
1M 时，ITG 的体水率显著高于 CTG（p=0.043）。同时，ITG 的空腹血糖水平（p=0.098）趋于低于 CTG。3M 时，ITG 的瘦体重（p=0.037）和肌肉量（p=0.035）显著高于 CTG，体重（p=0.044）显著低于 CTG。ITG 的体重指数（p=0.052）也趋于低于 CTG。
牙科干预联合生活方式指导可能改善人体测量学状态并降低 MetS 的风险。
大学医院医疗信息网络中心独特 UMIN000022753。https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026176。
