Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina.
Intensive Care Unit, Hospital Carlos Malbran, Catamarca, Argentina.
Crit Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x.
Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
维持足够的镇静和镇痛水平在创伤性脑损伤（TBI）的治疗中起着关键作用。迄今为止，尚不清楚哪种药物或药物组合在实现这些目标方面最有效。氯胺酮是一种具有有吸引力的药理学和药代动力学特性的药物。目前的证据表明，氯胺酮不会增加颅内压，反而可能降低颅内压，其安全性使其成为院前环境中的可靠工具。在这篇观点文章中，我们讨论了氯胺酮在 TBI 急性期使用的不同方面，包括其潜在的益处和陷阱。
