Turner A F, Presant C A, Proffitt R T, Williams L E, Winsor D W, Werner J L
Department of Radiology, San Gabriel Medical Center, CA 91776.
Radiology. 1988 Mar;166(3):761-5. doi: 10.1148/radiology.166.3.3340774.
Neutral phospholipid vesicles (liposomes) were loaded with 0.5 mCi (18.5 MBq) indium-111 and administered to 24 patients with various types of cancer. The median diameter of the liposomes was 77 nm, and lipid dose was 0.78-6.25 mg/kg. Scans obtained 24 and 48 hours after injection of In-111 liposomes showed gradual blood clearance with homogeneous uptake in the normal liver and spleen. Dosimetric estimates for these organs were 2.3 +/- 1.1 and 2.3 +/- 1.4 rad (.02 +/- .01 Gy), respectively, with a whole-body estimate of 0.28 rad (.003 Gy). Radiation dose did not correlate with lipid dose. Total renal excretion of In-111 was less than 2% of the injected dose in all but two patients. Transient eosinophilia occurred in two patients. Tumor was seen in the scans of 22 of 24 patients (unbinded readings). In-111-labeled liposomes may enable the demonstration of suspected or unsuspected sites of tumor.
将0.5毫居里（18.5兆贝可）的铟-111装入中性磷脂囊泡（脂质体）中，并给予24例患有各种类型癌症的患者。脂质体的中位直径为77纳米，脂质剂量为0.78 - 6.25毫克/千克。注射铟-111脂质体后24小时和48小时获得的扫描显示，血液逐渐清除，正常肝脏和脾脏呈均匀摄取。这些器官的剂量测定估计值分别为2.3±1.1和2.3±1.4拉德（0.02±0.01戈瑞），全身估计值为0.28拉德（0.003戈瑞）。辐射剂量与脂质剂量无关。除两名患者外，所有患者铟-111的总肾排泄量均低于注射剂量的2%。两名患者出现短暂性嗜酸性粒细胞增多。24例患者中有22例在扫描中发现肿瘤（未结合读数）。铟-111标记的脂质体可能有助于显示可疑或未被怀疑的肿瘤部位。
