Kyriazis Marios, Swas Lama, Orlova Tetiana
National Gerontology Centre, Larnaca 6043, Cyprus.
J Clin Med. 2023 Aug 21;12(16):5433. doi: 10.3390/jcm12165433.
The primary objective of researchers in the biology of aging is to gain a comprehensive understanding of the aging process while developing practical solutions that can enhance the quality of life for older individuals. This involves a continuous effort to bridge the gap between fundamental biological research and its real-world applications.
In this narrative review, we attempt to link research findings concerning the hormetic relationship between neurons and germ cells, and translate these findings into clinically relevant concepts.
We conducted a literature search using PubMed, Embase, PLOS, Digital Commons Network, Google Scholar and Cochrane Library from 2000 to 2023, analyzing studies dealing with the relationship between hormetic, cognitive, and reproductive aspects of human aging.
The process of hormesis serves as a bridge between the biology of neuron-germ cell interactions on one hand, and the clinical relevance of these interactions on the other. Details concerning these processes are discussed here, emphasizing new research which strengthens the overall concept.
This review presents a scientifically and clinically relevant argument, claiming that maintaining a cognitively active lifestyle may decrease age-related degeneration, and improve overall health in aging. This is a totally novel approach which reflects current developments in several relevant aspects of our biology, technology, and society.
衰老生物学领域的研究人员的主要目标是全面了解衰老过程，同时开发切实可行的解决方案，以提高老年人的生活质量。这需要持续努力弥合基础生物学研究与其实际应用之间的差距。
在这篇叙述性综述中，我们试图将有关神经元与生殖细胞之间的兴奋效应关系的研究结果联系起来，并将这些结果转化为临床相关概念。
我们使用PubMed、Embase、PLOS、数字公共网络、谷歌学术和Cochrane图书馆对2000年至2023年的文献进行了检索，分析了涉及人类衰老的兴奋效应、认知和生殖方面之间关系的研究。
兴奋效应过程一方面是神经元 - 生殖细胞相互作用生物学之间的桥梁，另一方面是这些相互作用的临床相关性之间的桥梁。此处讨论了这些过程的详细信息，重点强调了加强整体概念的新研究。
本综述提出了一个具有科学和临床相关性的观点，即保持认知活跃的生活方式可能会减少与年龄相关的退化，并改善老年人的整体健康状况。这是一种全新的方法，反映了我们生物学、技术和社会几个相关方面的当前发展。
