Fiester Peter, Baig Saif Ahmed, Patel Jeet, Rao Dinesh
Department of Neuroradiology, University of Florida Health Jacksonville, Jacksonville, Florida, United States.
J Clin Imaging Sci. 2020 Dec 18;10:83. doi: 10.25259/JCIS_49_2020. eCollection 2020.
The medial longitudinal fasciculus (MLF) is a paired, highly specialized, and heavily myelinated nerve bundle responsible for extraocular muscle movements, including the oculomotor reflex, saccadic eye movements an smooth pursuit, and the vestibular ocular reflex. Clinically, lesions of the MLF are classically associated with internuclear ophthalmoplegia. However, clinical manifestations of a lesion in the MLF may be more complex and variable. We provide an overview of the neuroanatomy, neurologic manifestations, and correlative examples of the imaging findings on brain MRI of MLF lesions to provide the clinician and radiologist with a more comprehensive understanding of the MLF and potential clinical manifestations for an MLF lesion.
内侧纵束（MLF）是一对高度专业化且髓鞘丰富的神经束，负责眼球外肌运动，包括动眼反射、眼球扫视运动、平稳跟踪以及前庭眼反射。临床上，MLF损伤典型地与核间性眼肌麻痹相关。然而，MLF损伤的临床表现可能更为复杂和多样。我们概述了MLF的神经解剖、神经学表现以及MLF损伤的脑部MRI成像结果的相关实例，以便为临床医生和放射科医生提供对MLF及其损伤潜在临床表现的更全面理解。
