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Clinico-Aetiological Study of Severe and Very Severe Pneumonia in Two Months to Five Years Children in a Tertiary Health Care Centre in Odisha, India.印度奥里萨邦一家三级医疗保健中心针对2个月至5岁儿童严重及极重度肺炎的临床病因学研究
J Clin Diagn Res. 2017 Sep;11(9):SC06-SC10. doi: 10.7860/JCDR/2017/26027.10595. Epub 2017 Sep 1.
3
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PLoS One. 2013 Aug 7;8(8):e71311. doi: 10.1371/journal.pone.0071311. Print 2013.
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The X chromosome in immune functions: when a chromosome makes the difference.X 染色体在免疫功能中的作用:当染色体发挥作用的时候。
Nat Rev Immunol. 2010 Aug;10(8):594-604. doi: 10.1038/nri2815.
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Global, regional, and national causes of child mortality in 2008: a systematic analysis.2008 年全球、区域和国家儿童死亡原因:系统分析。
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Factors determining the outcome of children hospitalized with severe pneumonia.决定重症肺炎住院儿童预后的因素。
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Modifiable risk factors for acute lower respiratory tract infections.急性下呼吸道感染的可改变风险因素。
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2至60个月儿童急性下呼吸道感染的临床特征:一项观察性研究。

Clinical profile of acute lower respiratory tract infections in children aged 2-60 months: An observational study.

作者信息

Vinaykumar Nandimalla, Maruti Pawar Jalinder

机构信息

Department of Pediatrics, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

出版信息

J Family Med Prim Care. 2020 Oct 30;9(10):5152-5157. doi: 10.4103/jfmpc.jfmpc_624_20. eCollection 2020 Oct.

DOI:10.4103/jfmpc.jfmpc_624_20
PMID:33409180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7773121/
Abstract

BACKGROUND

Assessment of risk factors and clinical profile for acute lower respiratory tract infections (ALRIs) with severe and very severe pneumonia in children <5 years age is obligatory.

OBJECTIVE

To study the clinical profile, risk factors, and clinical outcomes associated with ALRIs in children aged 2-60 months.

METHODOLOGY

In total, 130 children of either gender, diagnosed with ALRIs, admitted in a tertiary care hospital were enrolled. Demographic data and clinical history was collected. Clinical profile data such as respiratory and heart rate, oxygen supplementation, ventilator use, and lab investigation such as erythrocyte sedimentation rate, hemoglobin, total leucocyte count, differential leucocytes count, and blood culture were analyzed and noted.

RESULTS

The study findings demonstrated male gender predominance for ALRIs with 1.3:1 male to female ratio. Around 16% of them had pneumonia, 61% had severe pneumonia, and 23% had very severe pneumonia. The birth weight of child, maternal and paternal literacy, socioeconomic status, overcrowding at home, immunization status of children, type of kitchen and fuel used for cooking, malnutrition, anemia, and need for oxygen supplementation were found to be associated with the occurrence of ALRIs ( < 0.05). Most of the presented symptoms were cough (100%), breathlessness (96.92%), and fever (92.31%). Bronchiolitis (63%), bronchopneumonia (27%), and lobar pneumonia (25%) were the major clinical outcomes.

CONCLUSION

The study identified various sociodemographic, environmental, and nutritional risk factors for ALRIs along with the clinical profile, which can be managed by effective peripheral health personnel's training and persuasive community health education.

摘要

背景

评估5岁以下儿童急性下呼吸道感染(ALRIs)伴严重和极严重肺炎的危险因素及临床特征是必要的。

目的

研究2至60个月儿童ALRIs的临床特征、危险因素及临床结局。

方法

共纳入130例诊断为ALRIs并入住三级护理医院的儿童,无论性别。收集人口统计学数据和临床病史。分析并记录临床特征数据,如呼吸和心率、吸氧情况、呼吸机使用情况,以及实验室检查结果,如红细胞沉降率、血红蛋白、白细胞总数、白细胞分类计数和血培养结果。

结果

研究结果显示,ALRIs以男性为主,男女比例为1.3:1。其中约16%患有肺炎,61%患有严重肺炎,23%患有极严重肺炎。发现儿童出生体重、父母文化程度、社会经济地位、家庭拥挤程度、儿童免疫状况、烹饪所用厨房类型和燃料、营养不良、贫血以及吸氧需求与ALRIs的发生相关(P<0.05)。出现的症状大多为咳嗽(100%)、呼吸急促(96.92%)和发热(92.31%)。细支气管炎(63%)、支气管肺炎(27%)和大叶性肺炎(25%)是主要的临床结局。

结论

该研究确定了ALRIs的各种社会人口学、环境和营养危险因素以及临床特征,可通过有效的基层卫生人员培训和有说服力的社区健康教育来加以应对。