Zinat Nooraia Jahan, Sultana Nasrin, Haq Md Mansurol, Rahman Md Mizanur, Afrose Marzia, Hossain Md Mossabbir, Alam Md Rafiqul
Department of Surgery and Obstetrics, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh, Bangladesh.
J Adv Vet Anim Res. 2020 Oct 7;7(4):647-654. doi: 10.5455/javar.2020.g463. eCollection 2020 Dec.
This study aimed to examine the effects of wet-to-dry bandages for the treatment of surgical wounds in goats.
Three types of bandages, i.e., the calcium alginate gel, the homogenous platelet-rich plasma (PRP) gel dressing, and saline dressing, were used to promote the healing process for the management of wounds. Artificial circular wounds were created and treated with bandages to evaluate their effects on the wound healing process in 12 goats. The morphological parameters, i.e., diameters (cm), duration of healing, and wound contraction (cm), were evaluated to differentiate the postoperative sequelae on wound healing process up to day 30 in three different treatment groups of goats. Tissue specimens from the wounds were examined histopathologically on 1st, 3rd, 7th, and 30th postoperative days. Finally, the obtained data were analyzed using the Statistical Package for the Social Sciences 19 software.
The current study revealed that the contraction diameter was higher in calcium alginate gel and PRP gel treated group when compared to the saline dressing group. Aggregation of immunoreactive cells (neutrophils, macrophages, and lymphocytes), collagen fiber bundles among the cells, and proliferation of blood vessels were observed in the epidermis of calcium alginate gel, PRP gel treated and saline dressing wounds, which promote the healing process of wounds. In visual inspection, the number of reactive cells and proliferation of blood vessels were higher in the calcium alginate gel and PRP gel treated group than the saline dressing.
In terms of epithelialization, epidermal characteristics, neovascularization, and infiltration of immunoreactive cells, the calcium alginate gel and the homogenous PRP gel dressings showed the best healing performance. Therefore, the present study suggests that clinicians could consider the calcium alginate gel dressing and homogenous PRP gel dressing as beneficial for wound care.
本研究旨在探讨湿-干绷带对山羊手术伤口治疗的效果。
使用三种类型的绷带，即海藻酸钙凝胶、均质富血小板血浆（PRP）凝胶敷料和生理盐水敷料，以促进伤口愈合过程。制作人工圆形伤口并用绷带进行处理，以评估其对12只山羊伤口愈合过程的影响。评估形态学参数，即直径（厘米）、愈合持续时间和伤口收缩（厘米），以区分三个不同治疗组山羊在术后30天内伤口愈合过程中的术后后遗症。在术后第1天、第3天、第7天和第30天对伤口组织标本进行组织病理学检查。最后，使用社会科学统计软件包19对获得的数据进行分析。
当前研究表明，与生理盐水敷料组相比，海藻酸钙凝胶和PRP凝胶治疗组的收缩直径更高。在海藻酸钙凝胶、PRP凝胶治疗和生理盐水敷料伤口的表皮中观察到免疫反应细胞（中性粒细胞、巨噬细胞和淋巴细胞）聚集、细胞间胶原纤维束以及血管增生，这促进了伤口的愈合过程。在视觉检查中，海藻酸钙凝胶和PRP凝胶治疗组的反应细胞数量和血管增生高于生理盐水敷料组。
在上皮形成、表皮特征、新生血管形成和免疫反应细胞浸润方面，海藻酸钙凝胶和均质PRP凝胶敷料表现出最佳的愈合性能。因此，本研究表明临床医生可认为海藻酸钙凝胶敷料和均质PRP凝胶敷料对伤口护理有益。
