Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.
North China Petroleum Bureau General Hospital, Renqiu, 062550, China.
J Cardiovasc Transl Res. 2021 Aug;14(4):744-753. doi: 10.1007/s12265-020-10087-4. Epub 2021 Jan 6.
Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of circulating microRNA-134 levels for APE. Four databases were searched to retrieve articles focusing on microRNA-134 detection in APE diagnosis. The Quality Assessment of Diagnostic Accuracy Studies-2 was used to evaluate the quality of the included literature. This meta-analysis included seven studies and 383 subjects. The microRNA-134 levels in APE patients were higher than those in controls (SMD = 2.84, z = 3.69, p < 0.001). The pooled sensitivity, specificity, and diagnostic odds ratio were 0.86 (0.72-0.94), 0.75 (0.66-0.82), and 19 (7-51), respectively. The positive and negative likelihood ratios were 3.4 (2.4-4.8) and 0.18 (0.08-0.40), respectively. The area under the summary receiver operating characteristic curve was 0.81 (0.77-0.84). Circulating microRNA-134 may be a new biomarker for the diagnosis of APE, but more tests and studies are needed to further explore and prove this. Trial registration number: PROSPERO registration #CRD42020184072.
急性肺栓塞（APE）是一种常见的突发静脉血栓栓塞症，发病率和死亡率都很高。有几项研究得出结论，miRNA-134 可能是 APE 的潜在生物标志物。然而，这些研究的灵敏度差异很大。本研究旨在评估循环 miRNA-134 水平对 APE 的诊断价值。检索了四个数据库，以获取有关 miRNA-134 在 APE 诊断中检测的文章。使用诊断准确性研究质量评估-2 来评估纳入文献的质量。本荟萃分析包括 7 项研究和 383 例受试者。APE 患者的 miRNA-134 水平高于对照组（SMD=2.84，z=3.69，p<0.001）。合并的敏感性、特异性和诊断比值比分别为 0.86（0.72-0.94）、0.75（0.66-0.82）和 19（7-51）。阳性和阴性似然比分别为 3.4（2.4-4.8）和 0.18（0.08-0.40）。汇总受试者工作特征曲线下面积为 0.81（0.77-0.84）。循环 miRNA-134 可能是 APE 诊断的一种新的生物标志物，但需要更多的测试和研究来进一步探索和证明这一点。试验注册号：PROSPERO 注册 #CRD42020184072。
