Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.
Department of Geriatric, ShuLan (HangZhou) Hospital, Hangzhou, 310000, Zhejiang Province, China.
J Cardiovasc Transl Res. 2021 Oct;14(5):912-920. doi: 10.1007/s12265-020-10093-6. Epub 2021 Jan 6.
Left atrial sphericity index (LASI) is one significant geometric remodeling parameter to evaluate the prognosis of atrial fibrillation (AF). We aimed to determine whether transthoracic echocardiography (TTE)-derived LASI may help predict the outcomes following AF radiofrequency catheter ablation (RFCA). This prospective study enrolled 190 consecutive AF patients who underwent TTE 24 h before RFCA. LASI was calculated as the ratio of left atrial maximum volume to spherical volume. After 1-year follow-up, 56 patients (29.5%) relapsed. Multivariate Cox regression showed that LASI (hazard ratio = 1.48, 95% Cl 1.15-1.92, P = 0.003) was an independent predictor of AF recurrence. Stratifying patients into four subgroups with different LAVI showed that high LASI value indicated a high risk of recurrence, especially in patients with mildly and moderately enlarged atria (the recurrence rate was 0% vs. 26.3%, P = 0.049; 9.5% vs. 40.9%, P = 0.018, respectively). In conclusion, TTE-derived LASI may be useful to predict AF recurrence after RFCA.
左心房球型指数（LASI）是评估心房颤动（AF）预后的一个重要的几何重构参数。我们旨在确定经胸超声心动图（TTE）衍生的 LASI 是否有助于预测 AF 射频导管消融（RFCA）后的结局。这项前瞻性研究纳入了 190 例在 RFCA 前 24 小时接受 TTE 的连续 AF 患者。LASI 计算为左心房最大容积与球形容积的比值。经过 1 年的随访，56 例患者（29.5%）复发。多变量 Cox 回归显示，LASI（风险比=1.48，95%Cl 1.15-1.92，P=0.003）是 AF 复发的独立预测因子。将患者分为 LAVI 不同的四个亚组，高 LASI 值表明复发风险较高，尤其是在心房轻度和中度增大的患者中（复发率为 0% vs. 26.3%，P=0.049；9.5% vs. 40.9%，P=0.018）。总之，TTE 衍生的 LASI 可能有助于预测 RFCA 后 AF 的复发。
