Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Department of Ophthalmology, Tokyo Metropolitan Police Hospital, Nakano, Nakano-ku, Tokyo, Japan.
PLoS One. 2021 Jan 7;16(1):e0245015. doi: 10.1371/journal.pone.0245015. eCollection 2021.
The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation glaucoma (PEG; n = 18) with a 12-month follow-up period were included in the study. The decreases in IOP and medication score from the baseline to the all-time-point were statistically significant (P < 0.001). The surgical success rates were 97.1%, 76.5%, and 44.0% at 3 months (90 days), 6 months (180 days), and 12 months (365 days), respectively. A mixed effect Cox model revealed that the type of glaucoma (POAG) was significantly associated with surgical failure (P = 0.044). Furthermore, the surgical success rate was significantly higher in eyes with PEG than it was in those with POAG (P = 0.019). Stand-alone ab interno trabeculotomy significantly lowered both the IOP and the medication score in patients with glaucoma, although almost one quarter of the cases needed additional glaucoma surgeries. The surgical success rate was significantly higher in eyes with PEG than it was in those with POAG.
本研究旨在评估单纯内路小梁切开术的 12 个月手术效果和预后因素。分析眼压（IOP）和药物评分的变化以及手术成功率。本研究纳入了 29 名患者的 34 只眼，这些患者患有原发性开角型青光眼（POAG；n=16）或原发性青光眼（PEG；n=18），随访时间为 12 个月。从基线到所有时间点，IOP 和药物评分的降低均具有统计学意义（P<0.001）。术后 3 个月（90 天）、6 个月（180 天）和 12 个月（365 天）的手术成功率分别为 97.1%、76.5%和 44.0%。混合效应 Cox 模型显示，青光眼类型（POAG）与手术失败显著相关（P=0.044）。此外，与 POAG 相比，PEG 眼的手术成功率显著更高（P=0.019）。单纯内路小梁切开术可显著降低青光眼患者的眼压和药物评分，尽管近四分之一的病例需要额外的青光眼手术。与 POAG 相比，PEG 眼的手术成功率显著更高。
