Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.
Transbound Emerg Dis. 2021 Nov;68(6):3048-3054. doi: 10.1111/tbed.13980. Epub 2021 May 6.
The emergence of mobile mcr genes mediating resistance to colistin is a critical public health issue that has hindered the treatment of serious infections caused by multidrug-resistant pathogens in humans and other animals. We report the emergence of the mcr-9.1 gene in a polymyxin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacter kobei infecting a free-living franciscana dolphin (Pontoporia blainvillei), threatened with extinction in South America. Genomic analysis confirmed the presence of genes conferring resistance to clinically relevant β-lactam [bla , bla , bla and bla ], aminoglycoside [aac(3)-IIa, aadA1, aph(3'')-Ib and aph(6)-Id], trimethoprim [dfrA14], tetracycline [tetA], quinolone [aac(6')-Ib-cr and qnrB1], fosfomycin [fosA], sulphonamide [sul2] and phenicol [catA1 and catB3] antibiotics. The identification of mcr-9.1 in a CTX-M-15-producing pathogen infecting a critically endangered animal is of serious concern, which should be interpreted as a sign of further spread of critical priority pathogens and their resistance genes in threatened ecosystems.
移动 mcr 基因介导对黏菌素的耐药性的出现是一个重大的公共卫生问题，它阻碍了对人类和其他动物中由多药耐药病原体引起的严重感染的治疗。我们报告了 mcr-9.1 基因在一株多黏菌素耐药型产超广谱β-内酰胺酶（ESBL）的肠杆菌科克氏菌（Enterobacter kobei）中出现，该菌感染了一只自由生活的弗氏前海豚（Pontoporia blainvillei），这种海豚在南美洲受到灭绝的威胁。基因组分析证实了存在赋予临床相关β-内酰胺[blaCTX-M-15、blaTEM-1、blaDHA-1 和 blaOXA-1]、氨基糖苷[aac(3)-IIa、aadA1、aph(3'')-Ib 和 aph(6)-Id]、三 代 四 环 素 [dfrA14]、四 环 素 [tetA]、喹 诺 酮 [aac(6')-Ib-cr 和 qnrB1]、磷 霉 素 [fosA]、磺 胺 类 [sul2]和 苯 乙 醇 [catA1 和 catB3]抗生素耐药性的基因。CTX-M-15 产生性病原体感染濒危动物中 mcr-9.1 的鉴定令人严重关切，这应被视为在受威胁的生态系统中，重要优先病原体及其耐药基因进一步传播的迹象。
