Pattison M E, Logan J L, Lee S M, Ogden D A
Department of Nephrology, University Medical Center, Tucson, AZ 85724.
Am J Kidney Dis. 1988 Feb;11(2):184-7. doi: 10.1016/s0272-6386(88)80210-5.
Strenuous exercise leading to heat stroke is known to cause rhabdomyolysis and acute renal failure in men, but there are no reports of this environmental illness in otherwise healthy women. We report the first case of heat and exercise induced acute renal failure in a young nonacclimated adult female following intense exertion in the Grand Canyon. This individual displayed the typical clinical features of exertional heat stroke including hyperpyrexia, CNS disturbance, rhabdomyolysis, oligoanuric acute renal failure, and disseminated intravascular coagulopathy. The pathophysiology is discussed as well as sexual differences in response to heat and exercise. The specific factors that may have predisposed this young woman to heat stroke from exertion are identified.
已知剧烈运动导致中暑会在男性中引发横纹肌溶解和急性肾衰竭，但尚无关于健康女性出现这种环境疾病的报道。我们报告了首例在大峡谷剧烈运动后，一名未适应环境的年轻成年女性因热和运动诱发急性肾衰竭的病例。该个体表现出劳力性中暑的典型临床特征，包括高热、中枢神经系统紊乱、横纹肌溶解、少尿性急性肾衰竭和弥散性血管内凝血。本文讨论了其病理生理学以及对热和运动反应的性别差异。还确定了可能使这名年轻女性易因运动而中暑的具体因素。
