Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Int J Oral Maxillofac Surg. 2021 Sep;50(9):1138-1146. doi: 10.1016/j.ijom.2020.12.011. Epub 2021 Jan 5.
Japan's aging society has an increasing incidence of oral cancer. This study investigated perioperative changes in quality of life (QoL) among 172 oral cancer patients (elderly ≥75 years vs non-elderly <75 years), pre-treatment, at treatment completion, and at 1, 3, and 6 months post-treatment, using the following Functional Assessment of Cancer Therapy - Head and Neck (FACT-H&N) subscales: physical well-being (PWB), social/family well-being (SWB), emotional well-being (EWB), functional well-being (FWB), additional head- and neck-specific concerns (H&N). SWB (P=0.026), H&N (P=0.024), and total FACT-H&N (P=0.009) scores were significantly lower in the elderly group than in the non-elderly group at 6 months post-treatment, especially for mastication items (H&N1, P=0.047; H&N11, P=0.004), but not for swallowing items (H&N5 and H&N7, both P> 0.05). PWB (P= 0.004), EWB (P< 0.001), and FWB (P= 0.022) scores in the non-elderly group were significantly higher at 6 months post-treatment than before treatment. In the elderly group, no subscale showed a better score at 6 months post-treatment. Post-treatment QoL in elderly oral cancer patients did not improve, unlike in non-elderly patients.
日本的老龄化社会口腔癌发病率不断上升。本研究调查了 172 例口腔癌患者（老年组≥75 岁与非老年组<75 岁）在治疗前、治疗完成时、治疗后 1、3 和 6 个月时的生活质量（QoL）的围手术期变化，采用以下癌症治疗功能评估 - 头颈部量表（FACT-H&N）的亚量表：身体状况（PWB）、社会/家庭状况（SWB）、情绪状况（EWB）、功能状况（FWB）、额外的头颈部特异性问题（H&N）。在治疗后 6 个月，老年组的 SWB（P=0.026）、H&N（P=0.024）和总 FACT-H&N（P=0.009）评分显著低于非老年组，尤其是在咀嚼项目（H&N1，P=0.047；H&N11，P=0.004），但在吞咽项目（H&N5 和 H&N7，均 P>0.05）中则没有差异。非老年组在治疗后 6 个月时的 PWB（P=0.004）、EWB（P<0.001）和 FWB（P=0.022）评分显著高于治疗前。在老年组中，没有一个亚量表在治疗后 6 个月时的评分更好。老年口腔癌患者的治疗后 QoL 没有改善，与非老年患者不同。
