鸟枪弹样脉络膜视网膜病变中的人类白细胞抗原分型
HLA typing in birdshot chorioretinopathy.
作者信息
Priem H A, Kijlstra A, Noens L, Baarsma G S, De Laey J J, Oosterhuis J A
机构信息
Department of Ophthalmology, University of Gent, Belgium.
出版信息
Am J Ophthalmol. 1988 Feb 15;105(2):182-5. doi: 10.1016/0002-9394(88)90183-3.
We examined 49 patients with birdshot chorioretinopathy in whom HLA typing had been performed. Of these 49 patients, 47 (95.9%) had the HLA-A29 antigen. The HLA-B12 (B44) antigen was also significantly associated with the disease, but this antigen is known to be in linkage disequilibrium with the antigen HLA-A29. The HLA-A2 antigen was less frequent in patients with birdshot chorioretinopathy than in the control group of normal European individuals (20% as compared to 44.6%).
我们检查了49例已进行HLA分型的鸟枪弹样脉络膜视网膜病变患者。在这49例患者中，47例（95.9%）具有HLA - A29抗原。HLA - B12（B44）抗原也与该疾病显著相关，但已知该抗原与HLA - A29抗原处于连锁不平衡状态。与正常欧洲个体的对照组相比，鸟枪弹样脉络膜视网膜病变患者中HLA - A2抗原的出现频率较低（分别为20%和44.6%）。
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