Baarsma G S, Priem H A, Kijlstra A
Eye Hospital, Rotterdam, The Netherlands.
Curr Eye Res. 1990;9 Suppl:63-8. doi: 10.3109/02713689008999422.
In 1980 Ryan and Maumenee described a new clinical entity characterized by hypopigmented spots in a typical patterned distribution in association with vitritis and retinal vasculopathy leading to cystoid macular oedema and papilloedema. In a recent study of a large group of European patients (n = 102) with birdshot retinochoroidopathy, the importance of the different clinical manifestations and their diagnostic value were assessed. Data on HLA-A29 typing were obtained in 49 patients with birdshot retinochoroidopathy. We could confirm the high association between HLA-A29 and this disease, as found by Nussenblatt in 1982. In 47 of these patients (95.5%) the HLA-A29 antigen was present. This association is presently the highest HLA class I disease association reported with a relative risk of 224.35.
1980年，瑞安和莫梅尼描述了一种新的临床病症，其特征为色素减退斑呈典型的图案状分布，并伴有葡萄膜炎和视网膜血管病变，进而导致黄斑囊样水肿和视乳头水肿。在最近一项针对一大组欧洲鸟枪弹样视网膜脉络膜病变患者（n = 102）的研究中，评估了不同临床表现的重要性及其诊断价值。49例鸟枪弹样视网膜脉络膜病变患者获得了HLA - A29分型数据。正如1982年努森布拉特所发现的那样，我们能够证实HLA - A29与这种疾病之间存在高度关联。在这些患者中有47例（95.5%）存在HLA - A29抗原。目前，这种关联是报道的HLA I类疾病关联中最高的，相对风险为224.35。
