头颈部癌症患者生存不平等：头颈部 5000 队列研究。
Inequality in survival of people with head and neck cancer: Head and Neck 5000 cohort study.
机构信息
School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK.
Centre for Trials Research, College of Biomedical and Life Science, Cardiff University, Cardiff, UK.
出版信息
Head Neck. 2021 Apr;43(4):1252-1270. doi: 10.1002/hed.26589. Epub 2021 Jan 8.
BACKGROUND
Explanations for socioeconomic inequalities in survival of head and neck cancer (HNC) patients have had limited attention and are not well understood.
METHODS
The UK Head and Neck 5000 prospective clinical cohort study was analyzed. Survival relating to measures of socioeconomic status was explored including area-based and individual factors. Three-year overall survival was determined using the Kaplan-Meier method. All-cause mortality was investigated via adjusted Cox Proportional Hazard models.
RESULTS
A total of 3440 people were included. Three-year overall survival was 76.3% (95% CI 74.9, 77.7). Inequality in survival by deprivation category, highest education level, and financial concerns was explained by age, sex, health, and behavioral factors. None of the potential explanatory factors fully explained the inequality associated with annual household income or the proportion of income of benefits.
CONCLUSION
These results support the interventions to address the financial issues within the wider care and support provided to HNC patients.
背景
社会经济地位对头颈部癌症（HNC）患者生存的影响的解释一直受到关注，并且理解得还不够透彻。
方法
对英国头颈部 5000 例前瞻性临床队列研究进行了分析。探讨了与社会经济地位衡量标准相关的生存情况，包括基于地区的因素和个体因素。使用 Kaplan-Meier 方法确定了 3 年总生存率。通过调整后的 Cox 比例风险模型研究了全因死亡率。
结果
共纳入 3440 人。3 年总生存率为 76.3%（95%CI74.9,77.7）。按贫困程度、最高教育程度和经济状况划分的生存不平等现象，可通过年龄、性别、健康状况和行为因素来解释。没有任何潜在的解释因素能够完全解释与家庭年收入或福利收入比例相关的不平等现象。
结论
这些结果支持针对 HNC 患者更广泛的护理和支持中存在的经济问题的干预措施。
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