Mellembakken Jan Roar, Mahmoudan Azita, Mørkrid Lars, Sundström-Poromaa Inger, Morin-Papunen Laure, Tapanainen Juha S, Piltonen Terhi T, Hirschberg Angelica Lindén, Stener-Victorin Elisabet, Vanky Eszter, Ravn Pernille, Jensen Richard Christian, Andersen Marianne Skovsager, Glintborg Dorte
Division of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway.
Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Endocr Connect. 2021 Feb;10(2):154-163. doi: 10.1530/EC-20-0527.
Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI.
From a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI < 25 kg/m2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles).
The median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m2. Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS.
Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.
肥胖被认为是多囊卵巢综合征（PCOS）女性发生心血管代谢风险的最强预测因素。本研究的目的是比较体重正常的PCOS女性与年龄及体重指数（BMI）相匹配的对照组女性的血压（BP）。
从一个包含2615名北欧种族个体的北欧横断面研究样本中，我们研究了一个亚队列，其中有793名BMI<25kg/m²的体重正常女性（根据鹿特丹标准，512名患有PCOS的女性以及281名年龄和BMI相匹配的对照组女性）。参与者接受了血压、身体成分（BMI、腰臀比）、血脂状况和空腹血糖的测量。数据以中位数（四分位数）表示。
患有PCOS的女性的年龄中位数为28（25，32）岁，BMI中位数为22.2（20.7，23.4）kg/m²。患有PCOS的女性收缩压为118（109，128）mmHg，而对照组为110（105，120）mmHg；舒张压为74（67，81）mmHg，而对照组为70（64，75）mmHg，两者P<0.001。BP≥140/90mmHg的女性在患有PCOS的女性中患病率为11.1%（57/512），而在对照组中为1.8%（5/281），P<0.001。在年龄≥35岁的女性中，BP≥140/90mmHg的患病率在患有PCOS的女性和对照组中相当（12.7%对9.8%，P = 0.6）。通过多元回归分析，发现患有PCOS的女性中与血压关联最强的因素是年龄、腰围和总胆固醇。
体重正常的PCOS女性的血压高于对照组。血压和代谢筛查对于年轻的体重正常的PCOS女性也具有相关性。
