J Am Chem Soc. 2021 Jan 20;143(2):644-648. doi: 10.1021/jacs.0c11793. Epub 2021 Jan 8.
Despite impressive advances in the construction of metal-organic frameworks (MOFs), the formation of networks from peptidic ligands is difficult, though they are sought after for their modularity and biocompatibility. Herein we present a peptide-metal framework that consists of helical oligoproline ligands and Zn/K (or Zn/Rb). The crystalline network contains pleated nanosheets with the metal ions aligned in strings. This unprecedented architecture derives from under-appreciated London dispersion interactions between the oligoproline ligands that play in concert with the metal coordination to create the network. Hence, the secondary structure of the peptidic ligand represents an additional control element for the creation of new MOF architectures. We anticipate that our results will instruct the design of further peptidic MOFs and enable the generation of versatile biocompatible materials.
尽管在金属有机骨架（MOFs）的构建方面取得了令人瞩目的进展，但由于其结构的复杂性和难度，由肽配体形成的网络仍然难以实现，尽管它们因其模块化和生物相容性而备受关注。在此，我们展示了一种由螺旋寡脯氨酸配体和 Zn/K（或 Zn/Rb）组成的肽-金属骨架。该结晶网络包含褶皱的纳米片，其中金属离子排列成串。这种前所未有的结构源于寡脯氨酸配体之间被低估的伦敦色散相互作用，这些相互作用与金属配位协同作用，共同形成了网络。因此，肽配体的二级结构代表了创造新的 MOF 结构的另一个控制因素。我们预计，我们的研究结果将指导进一步的肽 MOF 的设计，并能够生成多功能的生物相容性材料。
