School of Chemistry and Forensic Science, Supramolecular and Interfacial Chemistry, Ingram Building, The University of Kent, Canterbury CT2 7NZ, Kent, United Kingdom.
School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
ACS Macro Lett. 2023 Jul 18;12(7):908-914. doi: 10.1021/acsmacrolett.3c00304. Epub 2023 Jun 26.
The ability to rationally design biomaterials to form desired supramolecular constructs presents an ever-growing research field, with many burgeoning works within recent years providing exciting results; however, there exists a broad expanse of promising avenues of research yet to be investigated. As such we have set out to make use of the polyproline helix as a rigid, tunable, and chiral ligand for the rational design and synthesis of supramolecular constructs. In this investigation, we show how an oligoproline tetramer can be specifically designed and functionalized, allowing predictable tuning of supramolecular interactions, to engineer the formation of supramolecular peptide frameworks with varying properties and, consequently, laying the groundwork for further studies utilizing the polyproline helix, with the ability to design desired supramolecular structures containing these peptide building blocks, having tunable structural features and functionalities.
合理设计生物材料以形成所需的超分子结构的能力提出了一个不断发展的研究领域，近年来有许多新兴的工作提供了令人兴奋的结果；然而，仍有广泛的有前途的研究途径有待探索。因此，我们着手利用聚脯氨酸螺旋作为刚性、可调谐和手性配体，用于超分子结构的合理设计和合成。在这项研究中，我们展示了如何专门设计和功能化四聚体寡脯氨酸，允许预测超分子相互作用的调谐，以工程具有不同性质的超分子肽骨架的形成，从而为进一步利用聚脯氨酸螺旋的研究奠定基础，有能力设计包含这些肽构建块的所需超分子结构，具有可调谐的结构特征和功能。
