Brightwell Dominic F, Samanta Kushal, Watts Julie A, Fay Michael W, Palma Aniello
School of Chemistry and Forensic Science, Supramolecular and Interfacial Chemistry, Ingram Building, The University of Kent Canterbury CT2 7NZ Kent UK.
School of Chemistry, University of Birmingham Edgbaston Birmingham B15 2TT UK.
Nanoscale Adv. 2024 Dec 5;7(1):94-98. doi: 10.1039/d4na00762j. eCollection 2024 Dec 17.
The field of peptide based supramolecular biomaterials is fast evolving. These types of constructs have been shown to find applications in the fields of bioimaging, drug delivery and scaffolds for chemical reactions. However, the community typically focuses on the use of two specific classes of structured peptides: α-helices and β-sheets, clearly neglecting a unique peptide secondary structure: the polyproline helix. Herein, we report the first design, synthesis and characterization of polyproline based metallo-peptide nanoparticles. We demonstrate that rationally engineered polyproline helices can assemble in a divergent manner, into two types of nanoparticles. We also demonstrate that the primary sequence of the functionalised polyproline peptide is crucial to ensure a controlled assembly. This work clearly demonstrates that polyproline helices can be a powerful tool to achieve supramolecular assemblies of complex and responsive bioinspired nanomaterials.
基于肽的超分子生物材料领域正在迅速发展。这类构建体已被证明可应用于生物成像、药物递送和化学反应支架等领域。然而，该领域通常专注于使用两类特定的结构化肽：α-螺旋和β-折叠，明显忽略了一种独特的肽二级结构：聚脯氨酸螺旋。在此，我们报告了基于聚脯氨酸的金属肽纳米颗粒的首次设计、合成及表征。我们证明，经过合理设计的聚脯氨酸螺旋可以以不同的方式组装成两种类型的纳米颗粒。我们还证明，功能化聚脯氨酸肽的一级序列对于确保可控组装至关重要。这项工作清楚地表明，聚脯氨酸螺旋可以成为实现复杂且具有响应性的仿生纳米材料超分子组装的有力工具。
