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Common Inflammatory Markers in Polycystic Ovary Syndrome (PCOS): A BMI (Body Mass Index)-Matched Case-Control Study.多囊卵巢综合征（PCOS）中的常见炎症标志物：一项体重指数（BMI）匹配的病例对照研究。
J Obstet Gynaecol India. 2019 Jun;69(3):294-296. doi: 10.1007/s13224-018-1143-3. Epub 2018 Jun 19.
2
Cardiometabolic risk in polycystic ovary syndrome.多囊卵巢综合征中的心血管代谢风险。
Endocr Connect. 2018 Jul;7(7):R238-R251. doi: 10.1530/EC-18-0129. Epub 2018 May 29.
3
Novel biomarkers for cardiovascular risk prediction.用于心血管风险预测的新型生物标志物。
J Geriatr Cardiol. 2017 Feb;14(2):135-150. doi: 10.11909/j.issn.1671-5411.2017.02.008.
4
Leptin Levels in Women With Polycystic Ovary Syndrome: A Systematic Review and a Meta-Analysis.多囊卵巢综合征女性的瘦素水平：系统评价和荟萃分析。
Reprod Sci. 2017 May;24(5):656-670. doi: 10.1177/1933719116670265. Epub 2016 Oct 26.
5
Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries.肥胖和非肥胖多囊卵巢患者心脏风险标志物水平的评估。
Gynecol Endocrinol. 2017 Jan;33(1):43-47. doi: 10.1080/09513590.2016.1203893. Epub 2016 Jul 16.
6
Leptin and body mass index in polycystic ovary syndrome.多囊卵巢综合征中的瘦素与体重指数
Indian J Endocrinol Metab. 2016 May-Jun;20(3):324-8. doi: 10.4103/2230-8210.180005.
7
Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS.多囊卵巢综合征患者中瘦素与胰岛素抵抗标志物的相关性研究
Indian J Clin Biochem. 2016 Mar;31(1):104-7. doi: 10.1007/s12291-015-0499-8. Epub 2015 Apr 28.
8
Validity of adiponectin-to-leptin and adiponectin-to-resistin ratios as predictors of polycystic ovary syndrome.脂联素与瘦素比值及脂联素与抵抗素比值作为多囊卵巢综合征预测指标的有效性
Fertil Steril. 2015 Aug;104(2):460-6. doi: 10.1016/j.fertnstert.2015.05.007. Epub 2015 Jun 6.
9
Metformin and pioglitazone in polycystic ovarian syndrome: a comparative study.二甲双胍与吡格列酮治疗多囊卵巢综合征的对比研究
J Obstet Gynaecol India. 2012 Oct;62(5):551-6. doi: 10.1007/s13224-012-0183-3. Epub 2012 Oct 16.
10
Leptin-to-adiponectin, adiponectin-to-leptin ratios, and insulin are specific and sensitive markers associated with polycystic ovary syndrome: a case-control study from Bahrain.瘦素-脂联素、脂联素-瘦素比值和胰岛素是与多囊卵巢综合征相关的特异性和敏感性标志物：来自巴林的病例对照研究。
Metab Syndr Relat Disord. 2012 Apr;10(2):98-102. doi: 10.1089/met.2011.0075. Epub 2011 Nov 22.

多囊卵巢综合征女性的C反应蛋白、纤维蛋白原、瘦素和脂联素水平

C-Reactive Protein, Fibrinogen, Leptin, and Adiponectin Levels in Women with Polycystic Ovary Syndrome.

作者信息

Ozgokce Cagdas, Elci Erkan, Yildizhan Recep

机构信息

Department of Obstetrics and Gynecology, Private Van Akdamar Hospital, Van, Turkey.

Department of Obstetrics and Gynecology, University of Healty Sciences Umraniye Training and Research Hospital, Istanbul, Turkey.

出版信息

J Obstet Gynaecol India. 2020 Dec;70(6):490-496. doi: 10.1007/s13224-020-01331-7. Epub 2020 Aug 19.

DOI:10.1007/s13224-020-01331-7
PMID:33417636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7758390/
Abstract

BACKGROUND AND AIM

We aimed to compare the levels of clinical, biochemical, hormonal, and metabolic parameters as well as serum CRP, fibrinogen, leptin, and adiponectin in cases with PCOS and control group to investigate whether they play a role in the etiology of the syndrome.

MATERIALS AND METHODS

The present study included a total of 90 subjects, 45 subjects were diagnosed with PCOS (= 45) and 45 subjects served as control group (= 45). Serum CRP, fibrinogen, leptin, and adiponectin levels were analyzed for each subject.

RESULTS

Serum CRP, fibrinogen, and leptin were found to be higher (statistically significant) in the group with PCOS as compared to the control group (< 0.05). Serum Adiponectin was higher in the control group (statistically significantly) as compared with the patients in the PCOS group (< 0.05).

CONCLUSION

CRP and fibrinogen (cardiac risk factor markers) increase in women with PCOS. The levels of leptin which affects metabolism increase, whereas the levels of adiponectin decrease.

摘要

背景与目的

我们旨在比较多囊卵巢综合征（PCOS）患者与对照组的临床、生化、激素及代谢参数水平，以及血清CRP、纤维蛋白原、瘦素和脂联素水平，以研究它们是否在该综合征的病因中发挥作用。

材料与方法

本研究共纳入90名受试者，其中45名被诊断为PCOS（=45），45名作为对照组（=45）。对每位受试者的血清CRP、纤维蛋白原、瘦素和脂联素水平进行分析。

结果

与对照组相比，PCOS组的血清CRP、纤维蛋白原和瘦素水平更高（具有统计学意义）（<0.05）。与PCOS组患者相比，对照组的血清脂联素水平更高（具有统计学意义）（<0.05）。

结论

PCOS女性的CRP和纤维蛋白原（心脏危险因素标志物）升高。影响代谢的瘦素水平升高，而脂联素水平降低。