Metavarayuth Kamolrat, Sitasuwan Pongkwan, Zhao Xia, Lin Yuan, Wang Qian
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
ACS Biomater Sci Eng. 2016 Feb 8;2(2):142-151. doi: 10.1021/acsbiomaterials.5b00377. Epub 2016 Jan 11.
Adult stem cell research has been advanced in recent years because of the cells' attractive abilities of self-renewal and differentiation. Topography of materials is one of the key features that can be harnessed to regulate stem cell behaviors. Stem cells can interact with underlying material through nanosized integrin receptors. Therefore, the manipulation of topographical cues at a nanoscale level can be employed to modulate the cell fate. In this review, we focus our discussion on the different surface topographical cues, especially, with an emphasis on the viral nanoparticle-coated materials, and their effects on stem cell differentiation.
近年来，由于成体干细胞具有自我更新和分化的诱人能力，其研究取得了进展。材料的拓扑结构是可用于调控干细胞行为的关键特征之一。干细胞可通过纳米级整合素受体与底层材料相互作用。因此，在纳米尺度上操控拓扑线索可用于调节细胞命运。在本综述中，我们重点讨论不同的表面拓扑线索，特别是强调病毒纳米颗粒包被材料及其对干细胞分化的影响。
