Francis Nimmy K, Pawar Harpreet S, Ghosh Paulomi, Dhara Santanu
Biomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India.
ACS Biomater Sci Eng. 2016 Feb 8;2(2):188-196. doi: 10.1021/acsbiomaterials.5b00327. Epub 2016 Jan 26.
The purpose of the study is to develop a method of imparting radio-opacity to the silk fibers by stepwise 2,5-dimethoxy-2,5-dihydro-furan (DMDF)-iodine cross-linking reaction for suture fabrication with mechanical properties abiding with U.S. pharmacopeia guidelines along with non invasive imaging advantage in postoperative follow-up. Silk fibers isolated from were cross-linked with suitable concentration of DMDF linked with iodine under elevated temperature and pressure. Cross-linked fibers knitted into sutures were subjected to further testing.Computed tomography (CT) images on day 28 of in vivo studies showed mean radio-opacity value (MRV) of 213 ± 19.46 compared to the vertebral bone having value of 254.66 ± 0.51. Modified silk sutures demonstrated several advantages like high tensile strength (626 ± 23.3 MPa) and knot strength (388.6 ± 16.8 MPa) besides antimicrobial property. Encouraging preliminary in vitro and in vivo biocompatibility studies advocate the potential use of modified suture material in cardiac surgery, aneurysmal embolization surgeries, and arterio-venous occlusion surgeries.
本研究的目的是开发一种通过逐步进行2,5-二甲氧基-2,5-二氢呋喃（DMDF）-碘交联反应使丝纤维具有射线不透性的方法，用于制造符合美国药典指南机械性能的缝线，并在术后随访中具有非侵入性成像优势。从[具体来源未提及]分离的丝纤维在高温高压下与合适浓度的与碘相连的DMDF进行交联。将交联后的纤维编织成缝线并进行进一步测试。体内研究第28天的计算机断层扫描（CT）图像显示，平均射线不透性值（MRV）为213±19.46，而椎骨的值为254.66±0.51。改性丝缝线除了具有抗菌性能外，还表现出一些优点，如高拉伸强度（626±23.3 MPa）和打结强度（388.6±16.8 MPa）。令人鼓舞的初步体外和体内生物相容性研究表明，改性缝线材料在心脏手术、动脉瘤栓塞手术和动静脉闭塞手术中具有潜在用途。
