Department of Radiodiagnostics and Invasive Radiology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Department of Diagnostic Imaging, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Medicina (Kaunas). 2021 Jan 6;57(1):40. doi: 10.3390/medicina57010040.
This work focuses on the possibility of using the point shear wave elastography (pSWE) method for detecting biochemical markers in diffuse liver diseases. Additionally, this study addresses the issue of the influence of ultrasound factors on the pSWE quality indicators of the obtained measurements. A pSWE examination was performed on 139 patients (69 female and 70 male) diagnosed with diffuse liver disease. The average age for all patients was 50.7 ± 15.0 years (female: 52.7 ± 15.2 years; male: 48.8 ± 14.6 years). Of these 139 patients, 65 met the inclusion criteria regarding biochemical parameters. The pSWE quality indicators were related to abnormalities found in B-mode ultrasound. A strong positive correlation was found between the results of the pSWE and all biochemical indexes analysed, with the exception of age/platelet count (PLT), for which an average correlation was obtained. The greatest correlation was observed between the elastography and King's Score index. There was no correlation observed between elastography and any of the analysed parameters or biochemical indexes considered. The pSWE measurements were impaired by factors such as thick soft tissue, uneven hepatic surface, hepatomegaly and female gender. No statistically significant difference in pSWE quality indicators parameters was found between disease entities. pSWE seems to be a complementary method for detecting biochemical indexes, but its results can be influenced by numerous factors.
本研究旨在探讨使用点剪切波弹性成像（pSWE）方法检测弥漫性肝脏疾病生化标志物的可能性。此外，本研究还探讨了超声因素对所获得测量值的 pSWE 质量指标的影响。对 139 名被诊断为弥漫性肝病的患者（69 名女性和 70 名男性）进行了 pSWE 检查。所有患者的平均年龄为 50.7 ± 15.0 岁（女性：52.7 ± 15.2 岁；男性：48.8 ± 14.6 岁）。在这 139 名患者中，有 65 名符合生化参数纳入标准。pSWE 质量指标与 B 型超声发现的异常有关。pSWE 结果与分析的所有生化指标均呈强正相关，除年龄/血小板计数（PLT）外，平均相关。与 King 评分指数相关性最大。弹性成像与任何分析参数或生化指标均无相关性。弹性成像测量值受到软组织增厚、肝表面不均匀、肝肿大和女性等因素的影响。不同疾病实体之间的 pSWE 质量指标参数无统计学差异。pSWE 似乎是一种检测生化指标的补充方法，但结果可能受到多种因素的影响。
