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CECT5713 在通过微生物学和免疫调节阴道生态实现复发性流产或不明原因不孕的足月妊娠中的应用。

Application of CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem.

机构信息

Department of Galenic Pharmacy and Food Technology, Complutense University of Madrid, 28040 Madrid, Spain.

Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.

出版信息

Nutrients. 2021 Jan 6;13(1):162. doi: 10.3390/nu13010162.

DOI:10.3390/nu13010162
PMID:33419054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7825435/
Abstract

In this study, the cervicovaginal environment of women with reproductive failure (repetitive abortion, infertility of unknown origin) was assessed and compared to that of healthy fertile women. Subsequently, the ability of CECT5713 to increase pregnancy rates in women with reproductive failure was evaluated. Vaginal pH and Nugent score were higher in women with reproductive failure than in fertile women. The opposite was observed regarding the immune factors TGF-β 1, TFG-β 2, and VEFG. Lactobacilli were detected at a higher frequency and concentration in fertile women than in women with repetitive abortion or infertility. The metataxonomic study revealed that vaginal samples from fertile women were characterized by the high abundance of sequences, while DNA from this genus was practically absent in one third of samples from women with reproductive failure. Daily oral administration of CECT5713 (~9 log CFU/day) to women with reproductive failure for a maximum of 6 months resulted in an overall successful pregnancy rate of 56%. The probiotic intervention modified key microbiological, biochemical, and immunological parameters in women who got pregnant. In conclusion, CECT5713 has proved to be a good candidate to improve reproductive success in women with reproductive failure.

摘要

在这项研究中，评估了生殖失败（复发性流产、不明原因不孕）女性的宫颈阴道环境，并将其与健康生育女性进行了比较。随后，评估了 CECT5713 提高生殖失败女性妊娠率的能力。生殖失败女性的阴道 pH 值和 Nugent 评分高于生育女性。而 TGF-β1、TGF-β2 和 VEGF 等免疫因子则相反。生育女性阴道乳酸杆菌的检出率和浓度均高于复发性流产或不孕女性。元分类学研究表明，生育女性的阴道样本中存在大量的 序列，而生殖失败女性的三分之一样本中几乎不存在该属的 DNA。生殖失败女性每天口服 CECT5713（~9 log CFU/天）最多 6 个月，总妊娠成功率为 56%。益生菌干预改变了妊娠女性的关键微生物学、生化和免疫学参数。总之，CECT5713 已被证明是改善生殖失败女性生殖成功的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5729/7825435/61bc7f5b2cf0/nutrients-13-00162-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5729/7825435/61bc7f5b2cf0/nutrients-13-00162-g009.jpg
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