Danion François, van Rhijn Norman van, Dufour Alexandre C, Legendre Rachel, Sismeiro Odile, Varet Hugo, Olivo-Marin Jean-Christophe, Mouyna Isabelle, Chamilos Georgios, Bromley Michael, Beauvais Anne, Latgé Jean-Paul
Unité des Aspergillus, Institut Pasteur, 75015 Paris, France.
Centre d'infectiologie Necker Pasteur, Hôpital Necker-Enfants Malades, 75015 Paris, France.
J Fungi (Basel). 2021 Jan 6;7(1):30. doi: 10.3390/jof7010030.
Establishment of a fungal infection due to relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for , the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.
由……引起的真菌感染的建立依赖于空气中的分生孢子一旦穿透呼吸道后的有效萌发。然而,在这种真菌物种以及其他丝状真菌物种中,分生孢子萌发的特征尚未得到充分探索和理解。我们在此表明,……的萌发是异步的。如果营养环境和广泛的基因缺失可以改变……的萌发参数,那么在所有测试的萌发条件下异步性都会保持。尽管分生孢子萌发异步性的原因仍然未知,但异步性对于这种丝状真菌生物周期的完成至关重要。