Morris J C, Fulling K
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110.
Arch Neurol. 1988 Mar;45(3):345-9. doi: 10.1001/archneur.1988.00520270127033.
An 82-year-old cognitively healthy man was assessed longitudinally until very mild senile dementia of the Alzheimer type was diagnosed by clinical research criteria and documented by psychometric testing at age 85 years. Four months after diagnosis, Alzheimer's disease was confirmed neuropathologically. The diagnostic difficulties involved in distinguishing early senile dementia of the Alzheimer type-Alzheimer's disease from normal aging are examined and clinical and pathologic features useful for their discrimination are discussed.
一名82岁认知健康的男性接受了纵向评估，直至85岁时根据临床研究标准诊断为非常轻度的阿尔茨海默型老年痴呆症，并通过心理测量测试得到证实。诊断后四个月，经神经病理学确诊为阿尔茨海默病。本文探讨了将早期阿尔茨海默型老年痴呆症-阿尔茨海默病与正常衰老区分开来所涉及的诊断困难，并讨论了有助于鉴别两者的临床和病理特征。
