Morris J C, McKeel D W, Fulling K, Torack R M, Berg L
Department of Neurology, Washington University School of Medicine, St Louis, MO.
Ann Neurol. 1988 Jul;24(1):17-22. doi: 10.1002/ana.410240105.
Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the primary dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.
阿尔茨海默病（AD）的临床研究一直受到诊断不准确的限制。我们采用明确的临床纳入和排除标准来识别阿尔茨海默型老年痴呆症（SDAT）患者。在该样本连续进行的26次尸检中，所有受试者经组织学证实患有AD，且AD是主要的痴呆性疾病。26名SDAT受试者中有17名在轻度痴呆时就已被诊断出来。对两名对照受试者进行了神经病理学检查；两人均未发现AD。我们得出结论，即使在轻度阶段，SDAT的研究临床诊断标准也是有效的。
