Peking University People's Hospital, Musculoskeletal Tumor Center, No. 11 Xizhimen South Street, 100044, Beijing, China.
J Orthop Sci. 2022 Jan;27(1):235-241. doi: 10.1016/j.jos.2020.12.009. Epub 2021 Jan 5.
Chondroblastoma is a rare, benign, cartilaginous bone tumor derived from epiphyseal chondrocytes. Although the clinical characteristics and experience of surgical treatment of the smaller number of patients has been reported in the literature, it is difficult to draw conclusions about the clinical and radiographic features and the outcome for surgical treatment of this disease due to the rarity of chondroblastoma. This study was aiming to review the epidemiologic characteristics and outcome of surgical management for patients with chondroblastoma.
We performed a retrospective analysis of 92 patients with chondroblastoma. Clinical data, radiographic images, surgical treatment and outcome were analyzed. Eighty-two patients received the extensive intralesional curettage and ten cases had the En-block resection.
The most common site of disease was proximal femur (20.7%, 19/92), followed by distal femur (18.5%, 17/92) and proximal tibia (16.3%, 15/92). The secondary aneurysmal bone cyst component was most common for chondroblastoma of the small irregular bones, such as patella and foot. Four (4.3%, 4/92) cases receiving the extensive intralesional curettage developed the local recurrence, respectively two at the proximal tibia, one at the pelvis and one at the calcaneus. Time to local recurrence were respectively 14.5, 8.8, 27.0 and 5.6 months, with the average 14 months. Kaplan-Meier estimated survivorship curve of local recurrence-free survival rates of one, two and five years were respectively 97.7%, 96.2% and 93.9%. The mean Musculoskeletal Tumor Society (MSTS) score was 29.4. At the last follow-up, no one had the pulmonary metastasis and death associated with the disease.
Intralesional curettage plus local adjuvants can obtain satisfactory outcome for chondroblastoma.
Level IV.
成软骨细胞瘤是一种罕见的良性软骨源性骨肿瘤，来源于骺软骨细胞。虽然文献中已经报道了少数患者的临床特征和手术治疗经验，但由于成软骨细胞瘤的罕见性，很难得出关于该病的临床和影像学特征以及手术治疗结果的结论。本研究旨在回顾分析成软骨细胞瘤患者的手术治疗的流行病学特征和结果。
我们对 92 例成软骨细胞瘤患者进行了回顾性分析。分析了临床资料、影像学图像、手术治疗和结果。82 例患者行广泛的肿瘤内刮除术，10 例患者行整块切除术。
最常见的发病部位是股骨近端（20.7%，19/92），其次是股骨远端（18.5%，17/92）和胫骨近端（16.3%，15/92）。较小的不规则骨如髌骨和足部的成软骨细胞瘤，最常见的是继发性动脉瘤样骨囊肿成分。4 例（4.3%，4/92）接受广泛的肿瘤内刮除术的患者发生局部复发，分别为胫骨近端 2 例、骨盆 1 例和跟骨 1 例。局部复发的时间分别为 14.5、8.8、27.0 和 5.6 个月，平均为 14 个月。Kaplan-Meier 估计的局部无复发生存率的 1、2 和 5 年分别为 97.7%、96.2%和 93.9%。肌肉骨骼肿瘤学会（MSTS）评分平均为 29.4。末次随访时，无患者发生与疾病相关的肺转移和死亡。
肿瘤内刮除术加局部辅助治疗可获得满意的成软骨细胞瘤治疗效果。
IV 级。
