Crisostomo Bernardo Lopes, Daou Julia Pozzetti, Garcia Jairo Greco, Petrilli Marcelo DE Toledo, Viola Dan Carai Maia, Garcia Reynaldo Jesus
Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas HC-FMUSP, Departamento de Ortopedia e Traumatologia DOT, Disciplina de Ortopedia Oncológica, Sao Paulo, SP, Brazil.
Hospital Israelita Albert Einstein, Grupo de Ortopedia Oncológica, São Paulo, SP, Brazil.
Acta Ortop Bras. 2025 Apr 7;33(spe1):e283605. doi: 10.1590/1413-785220243201e283605. eCollection 2025.
To describe the clinical and imaging characteristics of chondroblastoma and identify possible factors related to joint complications.
This retrospective cohort study was carried out with data from the medical records of 23 patients diagnosed with chondroblastoma, subjecting them to statistical analyses.
In total, 19 patients were included, 12 (63.2%) of which were mean with a mean age of 13.6±3.5 year. The relation with the local dimension equaled 57.9%, higher in the apophysis of the greater trochanter: 95.2% (p<0.001). Based on imaging, 15.8% patients had an open physis; 55.6%, no damaged physeal line; 42.1%, cortical rupture; 21.1%, secondary aneurysmal bone cyst; 26.7%, violated cartilage; and all cases, medullary edema. 15.8% of cases showed local recurrence and no metastasis. Moreover, 46.7% of patients had relevant secondary osteoarthritis related to the aggressiveness of the tumor according to the Enneking classification (p= 0.041).
The clinical outcome of chondroblastoma show no relation to age, sex, location, physeal status, or presence of calcifications or secondary aneurysmal bone cyst. Progression to secondary osteoarthritis configured the most frequent non-oncological complication and showed a direct relation with the severity of the chondroblastoma.
描述软骨母细胞瘤的临床和影像学特征，并确定与关节并发症相关的可能因素。
本回顾性队列研究采用23例诊断为软骨母细胞瘤患者的病历数据进行统计分析。
共纳入19例患者，其中12例（63.2%）为平均年龄13.6±3.5岁。与局部范围的关系为57.9%，在大转子骨骺处更高：95.2%（p<0.001）。基于影像学，15.8%的患者骨骺开放；55.6%，骨骺线未受损；42.1%，皮质破裂；21.1%，继发性骨囊肿；26.7%，软骨侵犯；所有病例均有骨髓水肿。15.8%的病例出现局部复发且无转移。此外，根据Enneking分类，46.7%的患者因肿瘤侵袭性出现相关继发性骨关节炎（p=0.041）。
软骨母细胞瘤的临床结果与年龄、性别、位置、骨骺状态或钙化及继发性骨囊肿的存在无关。进展为继发性骨关节炎是最常见的非肿瘤性并发症，且与软骨母细胞瘤的严重程度直接相关。
